| Item | Specification |
| Product Name | Liquiritin |
| Synonyms | Liquiritoside; 7-Hydroxyflavanone 4′-O-glucoside; Licorice flavonoid; |
| CAS Number | 551-15-5 |
| Molecular Formula | C₂₁H₂₂O₉ |
| Molecular Weight | 418.39 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy / NMR |
| Production Method | Natural Plant Extraction & High-Purity Column Purification |
| Melting Point | 195–197°C |
| Boiling Point | 637.2±55.0 °C (Predicted) |
| Solubility | Soluble in hot water, ethanol, methanol and ether; slightly soluble in cold water and chloroform; insoluble in petroleum ether |
| Natural Source | Naturally extracted from Glycyrrhiza uralensis (licorice root), a major water-soluble flavonoid glycoside active ingredient in licorice |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store at -20°C in sealed, dark and dry conditions; avoid high temperature, strong light and oxidation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Liquiritin powder is a high-purity natural water-soluble licorice flavonoid glycoside active ingredient, available in 98% and 99% HPLC grades. Liquiritin (CAS 551-15-5), commonly known as, is a signature water-soluble bioactive monomer compound isolated from traditional licorice root. It is the glycoside form of Liquiritigenin, retaining the core flavanone activity while adding glucose glycosyl structure, which greatly improves water solubility and formula compatibility. Featuring stable molecular structure, excellent water solubility and ultra-high safety, it integrates powerful antioxidant, broad-spectrum anti-inflammatory, skin brightening, neuroprotective and hepatoprotective effects, widely applied in water-based soothing skincare, brightening cosmetics, liver protection health supplements and biomedical pharmacological research. As a professional bulk Liquiritin supplier, we provide high-purity, stable-batch and fully compliant products for global industrial and scientific research clients.
Liquiritin belongs to the flavonoid glycoside subclass, composed of a flavanone parent nucleus and glucose group, which endows it with unique water-soluble advantages that fat-soluble licorice flavonoids do not possess. Its core functional mechanism activates the Nrf2/ARE endogenous antioxidant pathway and inhibits NF-κB and MAPK inflammatory signaling cascades, efficiently scavenging intracellular reactive oxygen species, reducing oxidative stress damage, and significantly lowering the release of pro-inflammatory factors such as TNF-α and IL-6. Different from aglycone Liquiritigenin, Liquiritin has better water solubility, making it more suitable for water-based skincare formulas, functional beverages and oral liquid health products. In skincare applications, it inhibits melanin migration and deposition, fades pigmentation, brightens dull skin and repairs sensitive barriers. In pharmacological research, it exerts significant liver protection, nerve protection and anti-oxidative damage activity, with stable efficacy and no toxic side effects for long-term use.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Liquiritin powder adopts low-temperature water-phase selective extraction and multi-stage high-precision column chromatography purification technology. We select high-quality natural licorice root raw materials with stable active content, completely remove licorice polysaccharides, plant fibers, macromolecular impurities and invalid components through gradient elution purification, and fully retain the complete glycoside active structure and biological activity of Liquiritin. The entire production process strictly avoids harmful solvent residues and chemical synthetic additives, fully complying with cosmetic-grade, food-grade and research-grade safety standards. The mature and stable production process ensures consistent batch purity, uniform powder appearance and reliable activity stability, meeting the strict formula development and experimental requirements of global customers.
Every batch of Liquiritin powder undergoes strict multi-dimensional quality inspection, including HPLC purity testing, UV spectral characteristic verification and NMR structural identification to ensure accurate molecular structure and stable high purity. The finished white to pale yellow crystalline powder features low impurity content, excellent water solubility and organic solvent compatibility, and outstanding batch consistency. All products comply with international cosmetic additive regulations, natural functional ingredient safety standards and research-grade compound specifications, supporting safe and standardized application in skincare products, functional foods, health supplements and biomedical research projects.
We maintain sufficient inventory and complete qualification documents for bulk Liquiritin supply. Whether you need water-soluble anti-inflammatory brightening raw materials for skincare formulas, mild liver protection and antioxidant ingredients for health products, or high-purity licorice flavonoid glycoside compounds for oxidative stress, inflammation and neuroprotective pharmacological research, our Liquiritin powder is a cost-effective and reliable bulk raw material choice for global buyers.
Functions & Benefits
Nrf2 Antioxidant & Anti-Aging (Core Benefit)
Liquiritin is a classic water-soluble natural antioxidant derived from licorice. It activates the Nrf2/ARE antioxidant signaling pathway, efficiently scavenges DPPH, ABTS and intracellular reactive oxygen free radicals, inhibits cellular lipid peroxidation and oxidative DNA damage, enhances endogenous antioxidant defense capacity, and delays skin and systemic aging caused by long-term oxidative stress.
Broad-Spectrum Anti-Inflammatory & Sensitive Skin Soothing
This natural licorice flavonoid glycoside effectively inhibits NF-κB and MAPK inflammatory pathways, reduces the release of multiple pro-inflammatory cytokines, and relieves acute and chronic low-grade inflammation in the body. It calms skin redness, swelling and sensitivity caused by external irritation, stabilizes skin microecology, and delivers ultra-mild, non-irritating soothing effects suitable for long-term sensitive skin care.
Skin Brightening & Melanin Inhibition
As a mainstream brightening active ingredient in licorice series, Liquiritin effectively inhibits melanin synthesis and migration, reduces pigmentation precipitation, fades post-inflammatory dullness and acne marks, evens skin tone, and improves overall skin dullness and yellowness, achieving natural and gentle brightening effects without irritation.
Hepatoprotective & Metabolic Regulation
Modern pharmacological studies verify that Liquiritin protects liver cells from oxidative and toxic damage, inhibits liver inflammatory infiltration, optimizes liver metabolic and detoxification functions, reduces liver oxidative stress injury, and effectively improves liver sub-health conditions, serving as a safe natural liver-protective active ingredient.
Neuroprotective & Anti-Degeneration Effects
Liquiritin exerts significant neuroprotective activity, which can improve neuronal oxidative damage and degenerative changes, protect nerve cell activity, relieve neuroinflammation, and has important research value in improving cognitive function and delaying nerve aging.
Water-Soluble Barrier Repair & Hydration Stabilization
With excellent water solubility, Liquiritin is easily compatible with water-based formulas. It repairs damaged skin barriers, enhances skin water-locking capacity, reduces moisture loss, relieves dry and fragile skin, and maintains long-term skin hydration and stability.
Applications
Brightening & Sensitive Skin Skincare Products
Liquiritin is widely used in brightening essences, spot-fading skincare products, soothing repair lotions, sensitive skin care creams and water-based antioxidant formulas. It features excellent water solubility, gently brightens skin tone, calms inflammatory sensitivity, repairs skin barriers, and is a core mild brightening active ingredient in clean beauty systems.
Liver Protection & Antioxidant Health Supplements
Applied in liver protection detox formulas, antioxidant anti-aging dietary supplements and daily sub-health conditioning products. It protects liver cells, relieves chronic inflammation, enhances systemic antioxidant capacity, and provides mild and comprehensive body conditioning for long-term sub-health groups.
Water-Based Functional Food & Beverages
As a safe water-soluble natural flavonoid, Liquiritin is widely used in functional beverages, nutritional fortified drinks, liquid health products and daily dietary supplements. It improves product antioxidant activity and nutritional value with high safety and good taste compatibility.
Biomedical & Scientific Research
Widely used in Nrf2 antioxidant mechanism research, inflammatory pathway pharmacology, liver protection research, neuroprotection studies and licorice flavonoid structure-activity relationship research, serving as a standard high-purity water-soluble research compound for university laboratories and medical research institutions.
Natural Water-Soluble Functional Ingredient Development
Acts as a high-value water-soluble licorice flavonoid glycoside intermediate for innovative functional product development, supporting the research and iteration of brightening, soothing, antioxidant and liver-protective natural raw materials.
FAQ
Q1: What is Liquiritin powder used for?
A: Liquiritin (Liquiritin powder) is a high-purity water-soluble flavonoid glycoside extracted from licorice root. It is mainly used for gentle skin brightening and melanin inhibition, sensitive skin soothing and barrier repair, liver protection and anti-oxidation conditioning, as well as biomedical anti-inflammation and neuroprotective pharmacological research.
Q2: What is the difference between Liquiritin and Liquiritigenin?
A: Liquiritin is the water-soluble glycoside form with added glucose group, suitable for water-based formulas and oral liquids; Liquiritigenin is the fat-soluble aglycone form with higher cell permeability and endocrine regulation activity. The two complement each other in efficacy and application scenarios.
Q3: Is Liquiritin safe for long-term skincare and oral use?
A: Yes, Liquiritin is a pure natural licorice-derived active ingredient with ultra-mild properties, zero irritation and high biocompatibility. It complies with international cosmetic raw material standards and food-grade safety specifications, supporting long-term topical skincare and oral health product application.
Q4: What are the core advantages of Liquiritin?
A: Liquiritin has outstanding water solubility that most licorice active ingredients do not have, with mild and non-irritating brightening and soothing effects. It integrates anti-oxidation, anti-inflammation, liver protection and neuroprotection multi-effects, featuring wide formula applicability and extremely high safety.
Q5: How to store Liquiritin powder correctly?
A: Liquiritin powder is sensitive to high temperature, strong light and oxidation. It needs to be tightly sealed and stored at -20°C in a dark and dry environment. Standard low-temperature sealed storage ensures a 24-month valid shelf life.
Q6: Can I get free Liquiritin samples?
A: Yes, we provide free Liquiritin powder samples for skincare formula debugging, functional food beverage development and academic pharmacological research. Bulk orders support customized purity and packaging to meet diverse production and research needs.
