| Item | Specification |
| Product Name | Deguelin |
| Synonyms | Degueline; (-)-Deguelin; Rotenoisoflavone |
| CAS Number | 522-17-8 |
| Molecular Formula | C₂₃H₂₂O₆ |
| Molecular Weight | 394.42 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity (HPLC) | ≥98.0% / ≥99.0% (customizable) |
| Loss on Drying | ≤ 1.0% |
| Residue on Ignition | ≤ 0.2% |
| Testing Method | HPLC / UV-Vis Spectroscopy |
| Production Method | Plant Extraction & Purification / Semi-synthetic synthesis |
| Melting Point | 85°C – 87°C |
| Solubility | Soluble in ethanol, methanol, DMSO and chloroform; slightly soluble in hot water; insoluble in cold water |
| Natural Source | Naturally derived from Derris trifoliata, Lonchocarpus and other legume plants, belonging to natural rotenoid flavonoid compounds |
| Package | 1 kg/aluminum foil bag, 25 kg/fiber drum; custom packaging available |
| Storage | Store in a cool, dry place; keep tightly sealed and protected from light, heat and moisture |
| Shelf Life | 24 months when stored properly in original packaging |
Product Description
Our Deguelin powder is a high-purity natural rotenoid compound, available in 98% and 99% grades. Deguelin (CAS 522-17-8) is a rare bioactive flavonoid extracted from legume plants, widely known for its potent anti-proliferative, antioxidant and anti-inflammatory activities. It is extensively used in biomedical research, pharmaceutical intermediate development and natural bioactive ingredient studies. As a professional bulk Deguelin supplier, we provide high-purity and stable batch products for global research and industrial clients.
Deguelin belongs to the rotenoid family of natural flavonoids, featuring unique chemical structure and outstanding biological activity. Unlike common plant extracts, pure Deguelin exhibits targeted inhibitory effects on abnormal cell proliferation, with significant anti-tumor, anti-angiogenesis and anti-metastatic properties. It regulates multiple key signaling pathways in cells, effectively inducing apoptosis and arresting cell cycles, making it a core research compound in modern pharmacological and cancer research fields.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Deguelin powder adopts two mature production processes to meet diverse customer demands. For natural research-grade requirements, we use low-temperature selective extraction and high-precision column purification technology from natural plant raw materials, completely retaining original biological activity without solvent residues. For pharmaceutical and high-standard industrial applications, we provide semi-synthetic Deguelin with higher batch stability, uniform purity and excellent cost performance.
Every batch of Deguelin powder undergoes strict multi-stage quality testing, including HPLC purity analysis and UV-Vis spectral verification, ensuring consistent and reliable quality. All products comply with international laboratory and pharmaceutical raw material standards, with high stability and low impurity content, fully suitable for scientific research, formula development and pharmaceutical intermediate production.
We maintain sufficient inventory and complete qualification documents for bulk Deguelin supply. Whether for academic laboratory research, biomedical formula development or pharmaceutical intermediate processing, our high-purity Deguelin powder is a reliable and cost-effective raw material choice for global clients.
Functions & Benefits
Potent Anti-Proliferative & Anticancer Activity (Core Benefit)
Deguelin is well-known for its powerful anticancer properties, effectively inhibiting the proliferation of precancerous and cancer cells. It modulates multiple cellular signaling pathways such as NF-κB, Wnt and AMPK, induces cancer cell apoptosis, arrests cell cycle progression, and suppresses tumor angiogenesis and metastasis. It shows broad-spectrum inhibitory effects on various tumor types while maintaining low toxicity to normal cells.
High-Efficiency Antioxidant Protection
Deguelin delivers excellent free radical scavenging capacity, effectively eliminating intracellular reactive oxygen species and reducing oxidative stress damage. It inhibits lipid peroxidation, protects cellular DNA and membrane integrity, and relieves oxidative-induced cell aging and injury, providing stable antioxidant support for biomedical research.
Anti-Inflammatory & Immune Modulation
Deguelin significantly suppresses the release of pro-inflammatory cytokines and blocks chronic inflammatory response pathways. It alleviates persistent low-grade inflammation in tissues, reduces inflammatory lesion progression, and regulates immune cell activity, helping stabilize internal immune balance and inhibit inflammation-related pathological changes.
Anti-Angiogenic & Anti-Metastatic Effects
Deguelin can effectively inhibit tumor angiogenesis, cut off nutrient supply for tumor growth, and block tumor cell invasion and metastasis. It restricts tumor expansion and diffusion, showing great research value in tumor auxiliary treatment and anti-tumor mechanism exploration.
Cell Cycle Regulation & Autophagy Modulation
As a key research bioactive compound, Deguelin precisely regulates cell cycle distribution, inhibits abnormal cell division, and modulates cellular autophagy levels. It helps maintain normal cell growth metabolism and provides new research directions for cell biology and pathological mechanism studies.
Biomedical Research Value
With stable chemical properties and unique multi-target biological activity, Deguelin has become a hotspot compound in global biomedical, pharmacological and cancer research. It provides reliable experimental materials for new drug development, tumor mechanism research and natural active ingredient exploration.
Applications
Biomedical & Scientific Research
Deguelin is widely used in laboratory pharmacological research, tumor mechanism study, cell biology experiments and natural active substance research, serving as a standard research-grade reference compound and experimental raw material.
Pharmaceutical Intermediates
Applied in the development of anti-tumor and anti-inflammatory new drugs, used as a key synthetic intermediate for targeted therapeutic preparations and biomedical innovative formulations.
Natural Bioactive Ingredient Development
Used for the research and development of high-value natural active ingredients, applied in the screening of anti-tumor, antioxidant and anti-inflammatory functional raw materials.
Academic & Institutional Experiments
Supports university laboratory research, medical institution pharmacological experiments and pharmaceutical institute new drug project development, providing high-purity and stable experimental raw materials.
Biotechnology Industry
Applied in biotech product development, cellular pathway research and natural compound activity screening, promoting innovative progress in biomedical technology.
FAQ
Q1: What is Deguelin powder used for?
A: Deguelin powder is a high-activity natural rotenoid compound. It is mainly used for biomedical research, anti-tumor mechanism study, antioxidant and anti-inflammatory experiments, and pharmaceutical intermediate development.
Q2: Is Deguelin stable for experimental use?
A: Yes, our high-purity Deguelin powder features stable chemical properties, low impurity content and consistent batch activity. Strict quality control ensures reliable and repeatable experimental results for research use.
Q3: What are the core advantages of Deguelin?
A: Deguelin has multi-target biological activities including anti-tumor, antioxidant and anti-inflammation. It inhibits abnormal cell proliferation without obvious toxicity to normal cells, possessing high research and new drug development value.
Q4: How should Deguelin be stored?
A: Deguelin powder is sensitive to strong light and high temperature. It needs to be tightly sealed and stored in a cool, dry and dark environment. The valid shelf life is 24 months under standard storage conditions.
Q5: Can I get free Deguelin samples for research?
A: Yes, we provide free Deguelin powder samples for laboratory testing and academic research. Bulk orders support customized purity and packaging to meet different experimental and production needs.
