Product Introduction
| Item | Specification |
| Product Name | Theobromine |
| Synonyms | 3,7-Dimethylxanthine; Theobromine base; 3,7-Dihydro-3,7-dimethyl-1H-purine-2,6-dione |
| CAS Number | 83-67-0 |
| Molecular Formula | C₇H₈N₄O₂ |
| Molecular Weight | 180.16 g/mol |
| Appearance | White crystalline powder, odorless, bitter taste, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Pharmacological Activity Detection |
| Production Method | Natural Cacao Bean Extraction & Macroporous Resin Purification & Low-Temperature Recrystallization Technology |
| Melting Point | 345–350°C (lit., decomposition) |
| Boiling Point | 313.0°C at 760 mmHg (Predicted) |
| Density | 1.60 g/cm³ at 25°C |
| Flash Point | 147.2°C |
| Solubility | Slightly soluble in cold water, soluble in hot water, dilute acid and alkali solution; freely soluble in DMSO and methanol; insoluble in ethanol and chloroform; stable under dry and dark conditions |
| Core Feature | Classic natural methylxanthine alkaloid, mild adenosine receptor antagonist, dual cardiovascular and respiratory regulatory bioactive monomer |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid high temperature, humid environment and strong light to prevent structural decomposition and activity attenuation |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Theobromine (3,7-Dimethylxanthine) is a high-purity natural methylxanthine alkaloid with stable and comprehensive pharmacological activity, available in premium research grade and pharmaceutical API grade. Theobromine (CAS 83-67-0) is the characteristic bioactive monomer isolated and purified from cacao beans and tea leaves, belonging to the classic xanthine derivative family. Structurally similar to caffeine, Theobromine features a unique dimethyl-substituted purine skeleton, endowing it with milder central nervous system stimulation but stronger cardiovascular and respiratory regulatory effects. As a natural adenosine receptor antagonist and phosphodiesterase inhibitor, it exhibits prominent vasodilation, bronchodilation, cardiotonic and diuretic properties, occupying an essential position in cardiovascular pharmacology, respiratory physiology and natural drug research. As a professional bulk Theobromine supplier, we provide low-impurity, high-activity, batch-stable Theobromine raw materials for global pharmacological laboratories, pharmaceutical R&D institutions and fine chemical manufacturing enterprises.
Theobromine is a landmark methylxanthine alkaloid widely studied in modern natural medicinal chemistry, with highly differentiated pharmacological advantages compared with caffeine and other xanthine compounds. Its core mechanism lies in the competitive inhibition of adenosine A1 receptor signaling and phosphodiesterase activity, which effectively regulates intracellular cyclic nucleotide levels, relaxes vascular and bronchial smooth muscle, improves microcirculation, and enhances myocardial contractility. Different from caffeine’s strong central excitatory effect, Theobromine produces negligible stimulation on the human central nervous system, ensuring higher safety and milder pharmacological characteristics, making it ideal for long-term physiological regulation and preclinical drug research. In addition, Theobromine delivers significant lipid metabolism regulation, anti-inflammatory and antioxidant activities, capable of reducing intracellular lipid accumulation and relieving oxidative stress damage. It also possesses mild diuretic effects, assisting in body fluid metabolism regulation. With stable molecular structure and clear action targets, Theobromine has become a core tool compound for cardiovascular protection, respiratory smooth muscle research and xanthine alkaloid structure-activity relationship exploration. Our high-purity Theobromine eliminates crude extract impurities such as plant waxes, mixed xanthines and pigment residues, ensuring single-component purity and ultra-stable pharmacological activity for high-precision experimental research.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Theobromine adopts advanced low-temperature selective solvent extraction combined with macroporous resin gradient separation and multi-stage low-temperature recrystallization purification process. The entire production process strictly controls temperature, humidity and light shielding conditions, effectively avoiding structural hydrolysis and oxidative degradation of the xanthine skeleton. The closed oxygen-free production system thoroughly removes plant fiber residues, miscellaneous alkaloids, wax impurities and organic solvent traces, completely retaining the complete methylxanthine active skeleton and stable biological activity of Theobromine. The finished product presents uniform white crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Theobromine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and excellent experimental repeatability. The product features stable solubility in hot water and common organic solvents, good biochemical compatibility in cell culture and in vivo animal experiment environments, fully meeting the strict raw material requirements of cardiovascular protection mechanism research, respiratory smooth muscle regulation experiments, lipid metabolism research and xanthine derivative synthesis.
We maintain sufficient low-temperature light-proof inventory and complete qualification documents for bulk Theobromine supply. Whether you need standard methylxanthine alkaloid monomers for basic pharmacological research, positive control reagents for vasodilatory and bronchodilatory efficacy evaluation, or high-purity parent intermediates for new xanthine drug structural optimization, our premium Theobromine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Potent Vasodilatory & Cardiovascular Protective Activity (Core Benefit)
Theobromine acts as a classic natural vasodilator, effectively relaxing vascular smooth muscle, improving systemic microcirculation, enhancing myocardial contractility and regulating blood pressure stability. With mild and safe efficacy without obvious central nervous excitation, it is the gold-standard tool compound for cardiovascular pharmacological research.
Efficient Bronchodilatory & Respiratory Regulation
As a natural respiratory protective agent, Theobromine relieves bronchial smooth muscle spasm, improves airway patency, and alleviates bronchial inflammation and respiratory discomfort. It provides reliable experimental support for asthma and bronchial disease mechanism research.
Adenosine Receptor Antagonist & Phosphodiesterase Inhibitor
Theobromine specifically inhibits adenosine A1 receptor signaling and phosphodiesterase activity, regulates intracellular cyclic nucleotide metabolism, and modulates multiple physiological pathways including energy metabolism and inflammatory response, supporting multi-dimensional pharmacological mechanism research.
Diuretic & Metabolic Regulatory Effects
High-purity Theobromine exerts mild and efficient diuretic activity to promote body fluid metabolism, and significantly inhibits intracellular lipid accumulation, delivering dual regulatory effects on water-salt balance and lipid metabolism, with broad physiological research value.
High Single-Component Purity & Stable Batch Activity
Our Theobromine adopts full-process low-temperature purification and multi-stage impurity removal technology, completely eliminating mixed xanthine impurities, plant waxes and pigment interference in traditional cacao crude extracts. It ensures pure monomer activity, zero experimental interference and consistent batch pharmacological efficacy.
Excellent Biocompatibility & Wide Experimental Adaptability
Theobromine has stable solubility in hot water and common organic solvents, easy to prepare into homogeneous experimental stock solutions. It maintains stable biological activity in conventional cell and animal experiment environments, perfectly adapting to cardiovascular function tests, respiratory regulation experiments and alkaloid structure-activity relationship research.
Applications
Cardiovascular Pharmacology & Vascular Regulation Research
Used as a standard vasodilatory positive reagent for studying vascular smooth muscle relaxation, myocardial contractility regulation and microcirculation improvement mechanisms, widely applied in cardiovascular physiology and natural drug research laboratories.
Respiratory Physiology & Bronchial Protection Study
Served as the core experimental compound for exploring bronchial spasm relief, airway inflammation repair and respiratory smooth muscle regulation, supporting efficacy verification of natural anti-asthma and bronchial protective drugs.
Metabolic Regulation & Lipid Metabolism Research
Applied as a key research tool for intracellular lipid accumulation inhibition and energy metabolism regulation, providing new research perspectives for metabolic disorder and obesity-related mechanism study.
Xanthine Alkaloid Structure-Activity Relationship Research
Used as a typical 3,7-dimethylxanthine model compound for studying the pharmacological activity differences of methyl-substituted purine skeletons, enriching the theoretical system of methylxanthine medicinal chemistry.
Laboratory Teaching & Pharmacological Mechanism Demonstration
Provided as standard high-purity Theobromine reagent for natural pharmacology teaching experiments, cardiovascular and respiratory drug mechanism demonstration and xanthine alkaloid activity comparison tests, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Theobromine mainly used for?
A: Theobromine is a natural methylxanthine alkaloid with core cardiovascular and respiratory regulatory activities. It is mainly used for vasodilation and cardiovascular protection research, bronchial dilation and respiratory disease study, lipid metabolism regulation experiments and xanthine derivative drug development.
Q2: What is the difference between Theobromine and Caffeine?
A: Compared with caffeine, Theobromine has negligible central nervous system excitatory effects, higher safety and milder efficacy, while possessing stronger vasodilatory, bronchodilatory and diuretic activities, making it more suitable for physiological regulation and long-term preclinical research.
Q3: What are the core advantages of our Theobromine?
A: Our Theobromine adopts professional low-temperature recrystallization purification technology, featuring ultra-high single-component purity, zero mixed xanthine and plant impurity interference, stable vasodilatory and respiratory regulatory activity, and consistent batch quality, ensuring high-precision and repeatable pharmacological research results.
Q4: How to store Theobromine correctly?
A: Theobromine is sensitive to high temperature, humidity and strong light, prone to structural decomposition and activity loss. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Theobromine?
A: High-purity Theobromine is uniform white fine crystalline powder at room temperature, odorless with slight bitter taste, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Theobromine samples for testing?
A: Yes, we provide free Theobromine samples for cardiovascular protection mechanism research, respiratory regulation verification and xanthine alkaloid derivative synthesis experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
