Supply Top quality cooling agent WS-12 with CAS: 68489-09-8 with factory price

WS 12 is an agonist of TRPM8 receptor and a cooling agent. In HEK293 cells expressed recombinant mouse TRPM8, WS 12 (30 μM) increased [Ca2+]i. WS 12 exhibited potency with EC50 value of 3.7 μM and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 12 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 μM, respectively. WS 12 was efficacious in eliciting cooling sensation [2].

cooling agent WS-12 Functions:

first. cooling agent WS-12 Continuous and long lasting cooling and refreshing effect, having no hot, harsh and stinging sensation of Menthol and/or Peppermint.
second. Heat-Resistance: Heating under 200oC will not reduce the cooling effect, suitable to use on baking and other high temperature heating process.
third. Its cooling intensity can maintain 15-30 minutes, enriching the refreshing of product and having no burning pain, stabbing and numbness, it’s cooler than traditional Menthol products.
fourth. Low dosage: 30-100 mg/kg dosage will give good cooling effect.
fifth. Excellent compatibility with other flavors, it can enhance the effect of the flavors. It also can be combined using with other cooling agents.

cooling agent WS-12 Applications:

1. Daily use products: Toothpaste, oral products, Air Freshener, skin cream, shaving cream, shampoo, sunscreen, shower

2. Foods: Confectionery products, chocolate, dairy produce, beer, distilled spirit, beverage, Chewing Gum.

3. Medicines: Linctus, diminish inflammation ointment, dyspepsia, antipruritic, liniment, oral cavity acesodyne, heatstroke pill.

4. Other products: Cigarette, filter tip, tobacco, it also can be used in insectifuge.

How to Order:

1. Make sure your quantity need and Leave us message, with your mailed details shown: Including contact name, address information, contact phone, etc.
2. We send you a PI (Proforma Invoice) for price and payment detail.
3. Payment by Paypal or Western Union or T/T.
4. We arrange the delivery and update you the tracking number in time.

Q1: Could you provide free sample for test?
A1: We can provide you free sample for test, and you only need to pay the delivery cost.

Q2: Which payment terms do you accept?
A2: PayPal, T/T, West Union, Bank Transfer, etc.

Q3: What’s about the MOQ ?
A3: It depends on different products. Usually our MOQ is 5kg.

Q4: What’s the delivery lead time?
A4: We will make delivery within 1-2 days after receiving payment.

Q5: What about the delivery port?
A5: Main ports in China are available(Hong Kong, Shenzhen or Guangzhou).