Levodopa CAS 59-92-7 High Purity L-DOPA Powder

Product Introduction

Levodopa (CAS 59-92-7), also known as L-DOPA, (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid, is a white to off-white crystalline powder and the immediate metabolic precursor of dopamine. As a prescription Active Pharmaceutical Ingredient (API) of the Nervous System category, Levodopa is the gold-standard therapy for Parkinson’s disease and is routinely co-formulated with carbidopa or benserazide to inhibit peripheral decarboxylation. This product is supplied as pharmaceutical-grade raw material compliant with CP / USP / EP monographs, intended for qualified B2B buyers (pharma manufacturers, formulation labs, R&D).

Physical & Chemical Properties

Appearance: White or off-white crystalline powder

Assay (HPLC): ≥ 98.0% / ≥ 99.0% (CP / USP / EP available)

Specific Optical Rotation: -15.5° to -17.0° (c=1, 1M HCl)

Melting Point: 276 – 278 °C (dec.)

Boiling Point: ~448 °C @ 760 mmHg

Density: 1.468 g/cm³

Solubility: Slightly soluble in water and dilute HCl / formic acid; practically insoluble in ethanol, chloroform, ether

Loss on Drying: ≤ 0.5%

Residue on Ignition: ≤ 0.2%

Heavy Metals: ≤ 10 ppm

Storage: Store at 2–8 °C, protected from light, under inert atmosphere (N₂) recommended. Solutions are unstable – prepare fresh if dissolved.

Applications

Parkinson’s Disease (PD) – First-line oral therapy for idiopathic PD (tremor, rigidity, bradykinesia); available as Levodopa/Carbidopa fixed-dose (Sinemet® pattern) or controlled-release.

Secondary Parkinsonism & Extrapyramidal Disorders – Drug-induced tremor / post-encephalitic parkinsonism.

Pharmaceutical Intermediate – API synthesis, formulation R&D, stability studies, impurity profiling (related substances: methyldopa, 3-O-methyl-L-DOPA).

Research Use – Dopamine biosynthesis models, neurochemistry labs, L-DOPA challenge protocols.

FAQ

Q: What is Levodopa CAS 59-92-7 used for?

A: Levodopa is the primary API for Parkinson’s disease therapy, usually co-formulated with carbidopa. Also used as a pharma intermediate and neurochemistry research reagent.

Q: Do you supply Levodopa USP/EP grade?

A: Yes – we offer CP / USP / EP compliant batches with full COA (HPLC, chiral purity, heavy metals, residual solvents).

Q: Can I buy Levodopa powder in bulk?

A: We supply B2B only (pharma mfg, formulation labs, qualified distributors). MOQ starts at 5 kg; 5 kg / 25 kg drum standard.