Product Introduction
| Item | Specification |
| Product Name | Indomethacin |
| Synonyms | Indometacin; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid |
| CAS Number | 53-86-1 |
| Molecular Formula | C₁₉H₁₆ClNO₄ |
| Molecular Weight | 357.79 g/mol |
| Appearance | White to off-white crystalline powder, almost odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Detection |
| Production Method | Indole Heterocyclic Synthesis & Multi-Stage Purification & Low-Temperature Recrystallization |
| Melting Point | 158–162°C (lit.) |
| Boiling Point | 499.4°C at 760 mmHg |
| Density | 1.36 g/cm³ at 25°C |
| Flash Point | 255.8°C |
| Solubility | Soluble in acetone, slightly soluble in methanol, ethanol and chloroform, practically insoluble in water; stable in neutral dry environment, sensitive to strong light and high temperature |
| Core Feature | Classic indole-based NSAID, potent non-selective COX-1/COX-2 inhibitor, blocks prostaglandin synthesis, powerful anti-inflammatory, analgesic and antipyretic activity |
| Package | 10g/50g/100g sealed amber bottle, 1kg/5kg drum; vacuum moisture-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid strong light, high temperature and humid environment to prevent oxidation and structural degradation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Indomethacin is a high-purity indole-derived non-steroidal anti-inflammatory drug (NSAID) monomer with stable molecular structure and complete pharmacological activity, available in premium research grade and pharmaceutical grade. Indomethacin (CAS 53-86-1), chemically defined as 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid, is a classic functional indole compound in the indole biochemical family. It shares the core indole ring skeleton with Tryptophan, Melatonin, IAA and I3C, but possesses unique chlorobenzoyl and methoxy modified structural characteristics, forming a potent COX-targeted anti-inflammatory pharmacological activity. As a professional bulk Indomethacin supplier, we provide low-impurity, high-activity, batch-stable Indomethacin raw materials for global pharmacological research institutions, pharmaceutical R&D laboratories and biomedical synthesis enterprises.
Indomethacin occupies a core foundational position in inflammatory pharmacology, pain mechanism research and indole drug development. As a high-efficiency non-selective COX-1/COX-2 inhibitor, it effectively blocks prostaglandin biosynthesis, thereby exerting strong anti-inflammatory, analgesic and antipyretic effects. It is widely used in experimental studies on arthritis inflammation, tissue swelling, pain response and fever regulation. Beyond basic inflammation research, Indomethacin is commonly applied in pathological mechanism exploration of chronic inflammatory diseases, acute inflammation intervention and prostaglandin signal pathway verification. In pharmaceutical chemistry, its multi-substituted indole heterocyclic structure provides valuable modification sites, supporting the structural optimization and efficacy upgrading of new NSAID derivatives and indole-targeted therapeutic molecules. Compared with ordinary low-purity Indomethacin products with oxidative impurities and unstable inhibitory activity, our high-purity purified product eliminates synthetic intermediates, solvent residues and degradation by-products, ensuring single-component purity and stable COX inhibitory activity for accurate, repeatable pharmacological experimental data and reliable drug development results.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Indomethacin adopts advanced indole heterocyclic precision synthesis combined with low-temperature oxygen-free reaction and multi-stage gradient recrystallization purification process. The entire production process strictly controls reaction temperature, pH value and purification gradient, completely removing unreacted indole raw materials, chlorinated by-products and residual solvents. By avoiding high-temperature induced molecular structural damage and activity attenuation, the process fully retains the complete modified indole active skeleton and efficient COX inhibitory pharmacological activity of Indomethacin. The finished product presents uniform white to off-white crystalline powder, stable crystal form, no caking, no yellowing and no discoloration, fully complying with high-standard biomedical research grade and pharmaceutical raw material grade quality requirements.
Every batch of Indomethacin undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It ensures zero invalid impurity interference, ultra-low trace residues and consistent batch efficacy, providing reliable raw material guarantee for inflammation mechanism research, COX pathway pharmacological experiments and indole derivative drug synthesis. The product features stable solubility in organic solvents, excellent biochemical stability in experimental environments and outstanding pharmacological repeatability, fully meeting the strict raw material requirements of in vitro cell experiments, in vivo animal pharmacology tests and new drug formula development.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Indomethacin supply. Whether you need standard COX inhibitor monomers for inflammatory research, core reference substances for NSAID pharmacological verification, or high-purity modified indole intermediates for custom drug synthesis, our premium Indomethacin is a high-cost-performance and high-value biological fine chemical product choice for global buyers.
Functions & Benefits
Potent COX-1/COX-2 Inhibitory Activity (Core Benefit)
Indomethacin is a classic high-efficiency non-selective cyclooxygenase inhibitor, which can significantly inhibit COX enzyme activity, block prostaglandin synthesis, and effectively intervene in inflammatory response, pain conduction and fever reaction. It is the core standard tool compound for inflammation pharmacology research.
Typical Modified Indole Heterocyclic Compound
As an important functional derivative of the indole compound family, Indomethacin complements the indole metabolic and functional system. Its unique multi-substituted indole structure enriches the research of structure-activity relationship of indole drugs, supporting cross-domain exploration of indole biochemistry and medicinal chemistry.
Comprehensive Anti-Inflammatory, Analgesic & Antipyretic Efficacy
High-purity Indomethacin exhibits stable and powerful comprehensive pharmacological activities, effectively relieving inflammatory swelling, mechanical pain and thermal fever. It is widely used in mechanism verification of acute and chronic inflammation and drug efficacy evaluation of inflammatory diseases.
Low-Impurity Purification & Ultra-Stable Pharmacological Activity
Our Indomethacin adopts low-temperature oxygen-free anti-oxidation purification technology, removing oxidative degradation impurities and invalid intermediate residues. It solves the problem of decreased activity and unstable experimental data of conventional products, ensuring long-term stable pharmacological efficacy.
Strict Batch Consistency & High Experimental Repeatability
Synthesized and recrystallized under constant low-temperature sterile conditions, Indomethacin eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch inhibitory activity, suitable for long-term pharmacological research and high-precision drug screening experiments.
Good Solubility & Wide Experimental Adaptability
Indomethacin has good solubility in common organic solvents such as acetone and ethanol, easy to prepare into experimental stock solutions and pharmacological formula systems. It maintains stable activity in conventional experimental environments, perfectly adapting to cell experiments, animal model tests and drug formulation research.
Applications
Inflammatory Pharmacology & COX Pathway Research
Used as a standard high-purity COX inhibitor reagent for studying cyclooxygenase signal transduction, prostaglandin metabolic mechanism, inflammatory cell activation and pain fever regulation pathways. Widely applied in pharmacology laboratories and inflammatory disease research institutions.
Acute & Chronic Inflammation Mechanism Study
Served as the core positive drug monomer for acute inflammation edema, chronic arthritis inflammation and soft tissue injury inflammation experiments, supporting the efficacy verification and mechanism exploration of anti-inflammatory active substances.
NSAID Drug R&D & Structure-Activity Relationship Analysis
Applied as a classic reference compound for new non-steroidal anti-inflammatory drug development, guiding the structural optimization, efficacy screening and safety evaluation of indole-based anti-inflammatory molecules.
Indole Heterocyclic Derivative Synthesis
Used as a high-value modified indole skeleton intermediate for the synthesis of new indole anti-inflammatory, analgesic and antipyretic derivatives, supporting the innovative R&D of fine chemical pharmaceutical intermediates.
Laboratory Pharmacological Verification & Teaching Research
Provided as standard high-purity Indomethacin reagent for inflammatory pharmacology teaching experiments, drug efficacy comparative tests and pathway mechanism verification, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Indomethacin mainly used for?
A: Indomethacin is a classic indole-based NSAID and potent COX inhibitor. It is mainly used for inflammatory pharmacological research, COX/prostaglandin pathway mechanism verification, anti-inflammatory and analgesic drug efficacy evaluation, and indole heterocyclic pharmaceutical intermediate synthesis, with stable and efficient pharmacological activity.
Q2: What is the structural characteristic of Indomethacin?
A: Indomethacin is a multi-substituted modified indole compound, based on the core indole ring skeleton, equipped with chlorobenzoyl, methoxy and methyl functional groups. It is an important active derivative in the indole compound family, differing from nutritional and plant-regulatory indoles with specific medicinal pharmacological properties.
Q3: What are the core advantages of our Indomethacin?
A: Our Indomethacin adopts low-temperature oxygen-free purification and multi-stage recrystallization technology, featuring ultra-high single-component purity, zero residual intermediate interference, stable COX inhibitory activity and consistent batch efficacy. It effectively avoids experimental errors caused by product oxidation and impurity interference, ensuring high-precision pharmacological research results.
Q4: How to store Indomethacin correctly?
A: Indomethacin is sensitive to strong light, high temperature and humid environments, prone to oxidation and structural degradation leading to decreased activity. It must be stored in vacuum-sealed, low-temperature, cool and dry dark conditions. Standard sealed low-temperature storage ensures 24 months of stable shelf life and pharmacological activity.
Q5: What is the appearance of high-purity Indomethacin?
A: High-purity Indomethacin is uniform white to off-white crystalline powder at room temperature, almost odorless, stable crystal state, no caking, no discoloration and no deterioration precipitation.
Q6: Can I get free Indomethacin samples for testing?
A: Yes, we provide free Indomethacin samples for inflammatory mechanism research, COX inhibitory activity verification and indole derivative synthesis tests. Bulk orders support customized purity and professional anti-oxidation vacuum packaging to meet high-standard scientific research and pharmaceutical R&D needs.
