Product Introduction
| Item | Specification |
| Product Name | Guaiacol |
| Synonyms | 2-Methoxyphenol; Catechol monomethyl ether; o-Methoxyphenol |
| CAS Number | 90-05-1 |
| Molecular Formula | C₇H₈O₂ |
| Molecular Weight | 124.14 g/mol |
| Appearance | Colorless to pale yellow oily liquid or crystalline solid with characteristic smoky, sweet vanilla-like aroma |
| Purity (GC) | ≥99.5% (Food Grade / Pharma Grade, customizable) |
| Loss on Drying | ≤ 0.3% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | GC / HPLC / NMR / Mass Spectrometry |
| Production Method | Natural Wood Tar Extraction & High-Vacuum Distillation Purification |
| Melting Point | 27–29°C (lit.) |
| Boiling Point | 204–206°C (lit.) |
| Density | 1.129 g/cm³ at 25°C |
| Refractive Index | n20/D 1.542–1.545 |
| Solubility | Slightly soluble in water, freely soluble in ethanol, ether, chloroform and vegetable oils, excellent compatibility with flavor and cosmetic oil-phase systems |
| Natural Source | Naturally isolated from guaiac wood resin and wood tar, also present in tea, parmesan cheese and plant essential oils, a classic natural phenolic flavor monomer |
| FEMA Number | 2532 |
| Package | 1 kg/fluorinated bottle, 25 kg/plastic drum; custom packaging available |
| Storage | Store at 2-8°C in sealed, dark and dry conditions; avoid air oxidation and long-term light exposure |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Guaiacol is a high-purity natural phenolic monomer with 99.5% food and pharmaceutical grade GC purity. Guaiacol (CAS 90-05-1), also known as 2-Methoxyphenol or is the core parent raw material of vanilla-series and clove-series aromatic compounds. It features a unique warm smoky-sweet vanilla aroma and stable phenolic activity, serving as the essential synthetic precursor for Vanillin, Vanillyl Alcohol and Eugenol. Different from downstream derivative products focused on finished fragrance and skincare efficacy, Guaiacol specializes in upstream intermediate synthesis, flavor base tuning and natural antioxidant antisepsis, forming a complete industrial chain differentiation with Vanillin, Vanillyl Alcohol and Acetyleugenol. As a professional bulk Guaiacol supplier, we provide ultra-low impurity, high-activity natural Guaiacol raw materials for global flavor manufacturers, cosmetic formula developers and pharmaceutical synthesis enterprises.
Guaiacol belongs to the basic methoxyphenol family, with clear functional positioning differences from other series products. Compared with Vanillin (aldehyde structure, focused on fragrance fixing) and Vanillyl Alcohol (alcohol structure, focused on mild skincare repair), Guaiacol retains the most primitive and stable phenolic hydroxyl and methoxy dual active structure. It not only has natural flavor modulation capabilities, but also possesses stronger chemical reaction activity, being able to derive almost all vanilla and clove aromatic ingredients through methylation, acetylation and oxidation reactions. In terms of efficacy, it has moderate antioxidant, broad-spectrum antibacterial and expectorant pharmacological effects, balancing industrial synthesis value and natural biological activity, which is irreplaceable in fine chemical and flavor industry chain applications.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Guaiacol adopts natural guaiac wood tar low-temperature extraction and multi-stage high-vacuum precision distillation purification technology. We select high-quality natural wood raw materials with stable active components, strictly control distillation temperature and pressure, completely remove heavy metal residues, tar impurities, isomer mixtures and macromolecular invalid substances, and fully retain the complete active molecular structure and pure natural aroma of Guaiacol. The whole production process eliminates harmful solvent residues and chemical pollution, fully complying with FEMA food-grade, cosmetic-grade and pharmaceutical intermediate safety standards. The refined purification technology solves the defects of impure odor, high impurity content and unstable reaction activity of ordinary industrial-grade Guaiacol, ensuring excellent batch consistency and high conversion rate for downstream synthesis.
Every batch of Guaiacol undergoes strict multi-dimensional quality inspection, including GC high-precision purity testing, spectral characteristic verification, NMR structural identification and mass spectrometry molecular confirmation to ensure accurate molecular structure and ultra-high purity. The finished product features transparent and clear appearance, pure and layered smoky-sweet aroma, excellent solvent compatibility and stable chemical activity. All products meet international food additive specifications and fine chemical industry standards, supporting safe and efficient application in flavor blending, cosmetic fragrance modulation, pharmaceutical intermediate synthesis and biological research.
We maintain sufficient inventory and complete qualification documents for bulk Guaiacol supply. Whether you need core synthetic intermediates for vanilla flavor derivative production, natural base flavor tuning raw materials for food and daily chemicals, or high-purity phenolic monomers for antioxidant and antibacterial formula research, our Guaiacol is a cost-effective and high-value upstream raw material choice for global buyers.
Functions & Benefits
Core Synthetic Intermediate for Vanilla & Clove Derivatives (Core Benefit)
As the parent raw material of Vanillin, Vanillyl Alcohol and Eugenol, Guaiacol has extremely high chemical activity. It can undergo oxidation, reduction, acetylation and allylation reactions to synthesize almost all mainstream vanilla and clove aromatic ingredients, with high reaction conversion rate and low by-product rate, being the irreplaceable core intermediate in the natural flavor industry chain.
Unique Smoky-Sweet Base Flavor Tuning
Guaiacol has a distinctive warm smoky, woody and sweet vanilla base aroma. It can enrich the odor hierarchy of compound flavors, enhance the natural and warm texture of vanilla, milk and woody fragrances, cover harsh and chemical odors of synthetic flavors, and significantly improve the naturalness and durability of flavor formulas.
Natural Antioxidant & Formula Stabilization
With typical phenolic active structure, Guaiacol has excellent free radical scavenging capacity, which can effectively inhibit oil oxidation and lipid peroxidation, prevent food and cosmetic formula rancidity and discoloration, extend product shelf life, and stabilize formula flavor and efficacy.
Broad-Spectrum Antibacterial & Preservative Activity
Guaiacol features mild and efficient broad-spectrum antibacterial performance, which can inhibit the growth of common mold and bacteria in daily chemical and food products. It assists in formula antisepsis and preservation, reduces the addition of synthetic preservatives, and conforms to clean and natural formula development trends.
Pharmacological Expectorant & Anti-Inflammatory Effects
Modern pharmacological studies show that Guaiacol has significant expectorant, cough-relieving and anti-inflammatory activities. It can dilute sputum and relieve respiratory inflammation, and is widely used in the synthesis of respiratory pharmaceutical intermediates and related biomedical research.
Excellent Formula Compatibility & Modifiability
Guaiacol has good solubility and compatibility with various organic solvents, vegetable oils and polymer systems. It is easy to formulate and modify, not easy to precipitate or deteriorate, and can stably participate in various organic synthesis and formula compounding processes.
Applications
Flavor Intermediate & Food Flavor Blending
Guaiacol is widely used as the core synthetic intermediate for Vanillin, Eugenol and other high-end flavors. It is also directly added to baked goods, beverages, dairy products and tobacco flavors to provide natural smoky and sweet base notes, enrich flavor layers and improve product taste grade.
Cosmetic & Daily Chemical Fragrance Modulation
Applied in perfume, body care products, soap and household fragrance products. It provides warm woody vanilla base tone, harmonizes floral and fruity compound fragrances, enhances fragrance depth and durability, and improves the natural texture of daily chemical fragrance formulas.
Pharmaceutical Intermediate Synthesis
Used for the synthesis of expectorant, anti-inflammatory and local anesthetic drugs, as well as guaiacol sulfonate and other pharmaceutical compounds. It is a key raw material for respiratory system drug preparation and biomedical pharmacological research.
Natural Antioxidant & Preservative Additive
Added to oil-based cosmetics, natural daily chemicals and food products as an auxiliary antioxidant and preservative. It inhibits product oxidation deterioration and microbial growth, improves formula stability and safety, and supports clean label product upgrading.
Fine Chemical & Material Modification Research
As a basic high-purity phenolic monomer, it is widely used in organic synthesis mechanism research, phenolic resin modification and natural active ingredient derivation experiments, providing standard raw materials for new formula and new material innovation.
FAQ
Q1: What is Guaiacol used for?
A: Guaiacol is a high-purity natural phenolic monomer and core flavor intermediate. It is mainly used for synthesizing Vanillin/Eugenol vanilla-series derivatives, food flavor base tuning, cosmetic fragrance modulation, pharmaceutical expectorant intermediate synthesis, and natural antioxidant preservation.
Q2: What is the difference between Guaiacol and Vanillin?
A: Guaiacol is the upstream parent raw material of Vanillin. Guaiacol focuses on synthetic derivation and base flavor tuning with strong chemical activity; Vanillin is the downstream oxidized derivative, focusing on finished vanilla fragrance fixing and mild skincare efficacy. The two form a complete upstream and downstream flavor industry chain.
Q3: Is Guaiacol safe for food and cosmetic use?
A: Yes, our Guaiacol meets FEMA food-grade and cosmetic-grade safety standards. It is naturally extracted and high-vacuum purified with ultra-low impurities, featuring mild properties and high biocompatibility, safe for legal addition in food and daily cosmetic formulas.
Q4: What aroma does Guaiacol have?
A: Guaiacol presents a unique warm smoky woody and sweet vanilla aroma, softer and more layered than single vanilla flavor, which can enrich the depth of compound flavors and improve the natural warmth of products.
Q5: How to store Guaiacol correctly?
A: Guaiacol is sensitive to high temperature and air oxidation, easy to darken in color. It needs to be tightly sealed, protected from light, and stored at low temperature (2-8°C) in a dry environment to maintain stable aroma and activity for 24 months.
Q6: Can I get free Guaiacol samples?
A: Yes, we provide free Guaiacol samples for flavor formula debugging, pharmaceutical intermediate experiments and cosmetic fragrance development. Bulk orders support customized purity and packaging to meet industrial and research needs.
