Erigeron Breviscapus Extract Breviscapine CAS 116122-36-2 Improve Blood Circulation
Product Introduction
Breviscapine (CAS 116122-36-2), also known as DengZhanHuaSu (DZHS), is a standardized total flavonoid extract derived from the dried whole plant of Erigeron breviscapus (Vant.) Hand.-Mazz. (family Asteraceae), a medicinal herb native to the Yunnan Province of southwestern China at elevations of 1,200–3,500 meters. The extract is standardized to contain not less than 85% scutellarin (CAS 27740-01-8, C21H18O12, MW 462.36), a flavone glucuronide that serves as both the principal bioactive constituent and the pharmacopoeial marker compound for quality control.
Chemical Identification
| Parameter | Detail |
| Product Name (English) | Breviscapine / Breviscapin |
| Brand Name (Pharmaceutical) | DengZhanHuaSu (DZHS) |
| CAS Registry Number | 116122-36-2 |
| Active Component | Scutellarin (≥85% by HPLC) |
| Scutellarin CAS | 27740-01-8 |
| Scutellarin Molecular Formula | C21H18O12 |
| Scutellarin Molecular Weight | 462.36 g/mol |
| Chemical Class | Flavonoid (Flavone glucuronide) |
| Botanical Source | Erigeron breviscapus (Vant.) Hand.-Mazz. |
| Plant Family | Asteraceae (Compositae) |
| HS Code | 2938.90.90 (Glycosides, natural or reproduced) |
| EC Number | Not assigned (natural extract mixture) |
| Pharmacopoeia Status | Chinese Pharmacopoeia 2020, Volume I |
| NMPA Drug Approval | National Drug Approval Number (multiple) |
| GRAS Status | Not self-affirmed GRAS (pharmaceutical grade) |
Applications
Pharmaceutical Preparations
Breviscapine is manufactured as multiple NMPA-approved pharmaceutical dosage forms in China:
- Breviscapine Injection (DengZhanHuaSu Zhu She Ye): IV infusion for acute hospital use
- Breviscapine for Injection (lyophilized powder): Reconstituted before IV administration
- Breviscapine Tablets: Oral administration for post-stroke recovery and chronic management
- Breviscapine Dripping Pills: Sublingual/buccal absorption with improved bioavailability
- Breviscapine Granules: Oral suspension for elderly patients with dysphagia
Multiple pharmaceutical manufacturers in China produce branded and generic Breviscapine preparations. The market value of Breviscapine pharmaceutical products in China exceeds several billion RMB annually, making it one of the most commercially successful TCM-derived drugs.
Dietary Supplements & Nutraceuticals
Breviscapine is increasingly formulated into dietary supplement products targeting brain health, cognitive function, and cardiovascular wellness for the global market:
- Brain health & memory support capsules (200–400 mg Breviscapine, standardized to scutellarin)
- Cardiovascular health formulas (often combined with CoQ10, hawthorn, nattokinase)
- Anti-aging & longevity supplements (Nrf2 activation, antioxidant defense)
- Stroke recovery support supplements (post-stroke nutritional support)
- Sports nutrition — enhanced blood flow & oxygen delivery formulations
