Aescine (Escin) – CAS 6805-41-0 Triterpene Saponin from Horse Chestnut
Product Identification
| Item | Detail |
|---|---|
| Synonyms | Aescine; Escin; β-Escin; (EP/ESC: “Horse Chestnut Seed Extract, standardized to 20% escin”) |
| CAS RN | 6805-41-0 |
| EC Number | 229-880-6 (escin mixture) |
| Molecular Nature | Mixed triterpene saponins, predominantly β-escin (escin IIB); C₅₅H₈₆O₂₄-type aglycone + glucuronic / glucoside sugars |
| Botanical Source | Aesculus hippocastanumL. (horse chestnut seed); A. chinensis(Suo Luo Zi) |
| HS Code (ref) | 1302 / 2938 (extract / saponin) |
| Related SKU (upstream cluster) | Rutin NF11 CAS 90131-19-4; Troxerutin CAS 7085-55-4; Diosmin CAS 520-27-4; Hesperidin CAS 520-26-3 — Euro venotonic quintet |
Description
Aescine is the trimeric(triterpene) saponin mixture responsible for horse chestnut’s veno-active signal — primarily β-escin (escin IIB), which modulates VEGF, reduces IL-6/TNF-α, and lowers capillary permeability/fluid extravasation in CVI models. The EP/ESC monograph standardizes horse chestnut seed extract to 20% escin HPLC, which is the dominant bulk SKU globally; pure escin CAS 6805-41-0 ≥98% is the R&D/pharma fraction.
Five commercial buckets drive search & procurement:
- Venotonic – CVI & Hemorrhoids (Euro B2B king): horse chestnut 20% escin is the fifth member of the Euro phlebology quintet — Diosmin + Hesperidin + Rutin + Troxerutin + Aescine. CVI capsules, hemorrhoid tablets, leg-gel combos. Search cluster “horse chestnut extract 20% escin venotonic” is steady EU DTC+B2B.
- Sports Recovery & Topical Gel (DTC non-prescription): “arnica + escin” or “escin gel” for post-training bruise, ankle edema, shin soreness — EU pharmacy OTC staple; often blended with heparinoid or menthol.
- Cosmeceutical – Eye & Face (niche but loyal): “horse chestnut eye gel” is a fixed EU/UK search phrase (puffy eyes, morning edema); also “face roller with escin” for lymphatic de-puff. Low competition, high intent.
- Pharma / Historical: escin IV historical use in cerebral edema (largely superseded, but some Asian pharma markets still carry escin injection legacy SKUs — China/India channel).
- R&D / Reference: pure escin ≥98% HPLC for quantification of horse chestnut extracts, stability, formulation.
Applications
Venotonic & CVI – chronic venous insufficiency, leg heaviness, edema; “Horse Chestnut Extract 20% Escin” capsules/tablets; often blended Diosmin + Hesperidin + Rutin + Troxerutin + Aescine Euro quintet
Hemorrhoid Support – oral + topical combo, often with tribenoside or local anesthetic in EU Rx; DTC “horse chestnut hemorrhoid” steady
Sports & Trauma Topical – escin gel for bruise, ankle sprain, post-exercise edema; “Arnica + Escin” or “Escin + Heparinoid” combos common
Cosmeceuticals – eye gel (puffy eyes, AM edema), de-puff roll-on, “horse chestnut” lymphatic face serum; INCI Aesculus Hippocastanum (Horse Chestnut) Seed Extract
Pharma (legacy/Asia): escin injection historical (cerebral edema adjunctive, China/India pharma channel); decreasing but still a SKU inquiry
Reference Standard – pure Aescine ≥98% HPLC for horse chestnut extract QC
