Product Introduction
| Item | Specification |
| Product Name | Baicalin |
| Synonyms | Baicalein 7-O-β-D-glucuronide; 5,6-Dihydroxyflavone-7-glucuronic acid |
| CAS Number | 21967-41-9 |
| Molecular Formula | C₂₁H₁₈O₁₁ |
| Molecular Weight | 446.36 g/mol |
| Appearance | Light yellow fine crystalline powder, odorless, stable texture, no caking under sealed dry and dark storage conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Premium Functional Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Assay |
| Production Method | Natural Scutellaria Baicalensis Root Extraction + Acid Hydrolysis + Macroporous Resin Purification + Low-Temperature Recrystallization |
| Melting Point | 231–233°C (lit.) |
| Boiling Point | 836.6°C at 760 mmHg (Predicted) |
| Density | 1.737 g/cm³ at 25°C |
| Flash Point | 295.4°C |
| Solubility | Slightly soluble in water and cold ethanol, soluble in hot ethanol, methanol, DMSO and alkaline aqueous solutions; insoluble in chloroform and ether; stable in dry and dark environment, sensitive to strong light and high temperature |
| Core Feature | Signature flavonoid glycoside marker of Scutellaria baicalensis, multi-functional monomer with anti-inflammatory, antiviral, antioxidant and skin-protective dual application value |
| Package | 1g/5g/10g amber sealed bottle, 100g/1kg vacuum drum; moisture-proof & light-proof packaging, customized specifications supported |
| Storage | Store in vacuum-sealed, low-temperature, dry and dark conditions; avoid high temperature, strong light and humid air to prevent oxidative degradation and activity attenuation |
| Shelf Life | 24 months under standard sealed low-temperature dark storage |
Product Description
Baicalin (CAS 21967-41-9) is the predominant bioactive flavonoid glycoside monomer extracted and purified from the dried root of Scutellaria baicalensis, a classic medicinal herb widely used in traditional herbal medicine. Chemically defined as Baicalein 7-O-β-D-glucuronide, Baicalin features a unique flavone glucuronide structure that endows it with excellent chemical stability and diverse high-value biological activities. We supply premium research-grade and high-purity functional-grade Baicalin powder with strictly controlled impurities, ultra-high single-component purity and consistent batch activity, fully compliant with global laboratory pharmacological standards and cosmetic & functional ingredient production specifications. As the core quality marker active substance of Scutellaria baicalensis, Baicalin is extensively studied for its potent anti-inflammatory, antioxidant, antiviral, hepatoprotective, neuroprotective and skin-brightening effects, serving as an indispensable core tool compound for modern biomedical research and high-end natural functional product development.
Different from mixed scutellaria root extracts with complex components, pure Baicalin monomer has a clear molecular structure, definite pharmacological targets and stable bioavailability, ensuring accurate experimental repeatability and standardized product efficacy. It exerts multi-pathway regulatory effects on human physiological and pathological processes. In anti-inflammatory regulation, Baicalin significantly inhibits the activation of NF-κB, MAPK and other classic inflammatory signaling pathways, effectively reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β, and relieving acute and chronic inflammatory reactions. In antioxidant activity, its abundant phenolic hydroxyl groups can efficiently scavenge intracellular reactive oxygen species, inhibit lipid peroxidation, reduce oxidative stress damage, and protect cell membrane integrity, effectively delaying cellular aging and tissue damage.
Baicalin also exhibits broad-spectrum antiviral activity, inhibiting the replication of multiple viruses and blocking viral invasion and proliferation pathways, making it a key monomer for antiviral mechanism research. For organ protection, it delivers prominent hepatoprotective efficacy by repairing damaged hepatocytes, reducing liver oxidative injury and inhibiting hepatic inflammatory fibrosis; it also provides reliable neuroprotective and renal protective effects, improving neuronal activity and alleviating renal tissue damage caused by inflammation and oxidation. In addition, Baicalin can absorb ultraviolet rays, inhibit melanin synthesis and reduce skin inflammatory damage, possessing outstanding skin-soothing, brightening and anti-photoaging properties, which makes it a popular high-end raw material in the cosmetic industry.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our high-purity Baicalin adopts standardized industrial production processes including selective plant extraction, targeted acid hydrolysis, macroporous resin gradient purification and multi-stage low-temperature recrystallization. The entire production process is carried out in a closed, dust-free and light-shielded system to avoid structural damage and oxidative degradation of the flavonoid active skeleton, completely retaining the complete biological activity of Baicalin. The finished product presents uniform light yellow fine crystalline powder with stable texture, no agglomeration and no discoloration, eliminating plant fiber impurities, pigment residues, heavy metals and miscellaneous flavonoid interference.
Functions & Benefits
Powerful Anti-Inflammatory & Inflammatory Injury Relief
Baicalin efficiently blocks NF-κB and MAPK inflammatory signaling cascades, downregulates the expression of multiple pro-inflammatory factors, and alleviates acute and chronic systemic inflammation. It relieves tissue inflammatory damage caused by oxidative stress, serving as a core tool compound for inflammatory mechanism research and anti-inflammatory functional product development.
High-Efficiency Antioxidant & Anti-Aging Activity
Rich in active phenolic hydroxyl groups, high-purity Baicalin rapidly scavenges intracellular free radicals and reactive oxygen species, inhibits lipid peroxidation, reduces cellular oxidative damage, and delays tissue and cell senescence. It provides stable antioxidant protection and effectively improves oxidative aging symptoms.
Broad-Spectrum Antiviral Biological Effect
This natural flavonoid glycoside inhibits viral adhesion, invasion and replication, exerting broad-spectrum antiviral activity against various viruses. It is widely used in antiviral pharmacological mechanism research and auxiliary antiviral raw material development, with high safety and stable inhibitory efficacy.
Multi-Organ Protection (Liver, Nerve & Kidney)
Baicalin delivers excellent hepatoprotective effects by repairing injured hepatocytes, reducing liver inflammation and preventing hepatic fibrosis. It also protects neuronal cells from oxidative and inflammatory damage and improves renal microcirculation, realizing systematic multi-organ protective functions.
Excellent Skin Care & Anti-Photoaging Properties
Baicalin can absorb ultraviolet radiation, inhibit melanin hyperplasia, soothe skin inflammatory redness and repair UV-induced skin damage. It features brightening, anti-oxidation and anti-photoaging effects, being a high-value functional raw material for high-end skin care formulations.
Ultra-High Purity & Zero Experimental Interference
Adopting multi-stage fine purification and low-temperature recrystallization technology, our Baicalin completely removes miscellaneous flavonoids, plant impurities and solvent residues. It achieves 98%–99% single-component high purity with zero invalid impurity interference and stable batch pharmacological activity.
High Safety & Wide Application Compatibility
Derived from natural medicinal plants, Baicalin has low toxicity and excellent human body and cellular biocompatibility. It maintains stable biological activity in scientific experiments and product formulations, adapting to biomedical research, drug development, cosmetics and health care product production.
Applications
Inflammatory Pharmacology & Oxidative Stress Research
Widely used as a standard flavonoid monomer for exploring inflammatory signaling pathway regulation, free radical scavenging and oxidative damage repair mechanisms, supporting chronic inflammation and oxidative disease pharmacological research.
Antiviral Mechanism & Biomedical Research
Served as a core experimental compound for viral replication inhibition and antiviral mechanism exploration, extensively applied in antiviral biomedical research and new antiviral drug screening experiments.
Hepatic, Neural & Renal Protection Studies
Applied in liver injury repair, neuroprotection and renal microcirculation regulation experiments, providing key monomer tools for multi-organ protection mechanism research and related chronic disease auxiliary intervention studies.
High-End Cosmetic & Skin Care Formulation
Used as a functional additive for anti-photoaging, antioxidant, soothing and brightening skin care products, effectively improving UV damage, inflammatory redness and dull skin problems, suitable for high-end cosmetic formula development.
Natural Flavonoid Structure-Activity Relationship Research
As a typical flavonoid glucuronide marker compound, it is used for comparative analysis of the structure and activity differences of flavonoid glycosides and aglycones, supporting natural active ingredient structure-activity relationship research.
FAQ
Q1: What is Baicalin mainly used for?
A: Baicalin is the core active flavonoid glycoside of Scutellaria baicalensis. It is mainly used for anti-inflammatory, antioxidant and antiviral pharmacological research, multi-organ protection mechanism studies, as well as high-end antioxidant and brightening cosmetic raw material and functional health product development.
Q2: What is the difference between Baicalin and Baicalein?
A: Baicalin is the 7-O-glucuronide glycoside of Baicalein. Baicalin has better water solubility, higher stability and wider industrial application adaptability, while Baicalein is the aglycone form with stronger lipophilic activity. Baicalin is the official quality detection marker of Scutellaria baicalensis.
Q3: What are your product advantages?
A: Our Baicalin adopts multi-stage high-precision purification technology, reaching 98%–99% ultra-high purity, free of miscellaneous flavonoid and plant impurity interference. It features stable anti-inflammatory, antioxidant and antiviral activity, excellent batch consistency and high experimental repeatability.
Q4: How to store Baicalin correctly?
A: Baicalin is sensitive to strong light, high temperature and humid environment, easy to oxidize and deactivate. It must be stored in vacuum-sealed, low-temperature, dry and dark conditions to ensure 24 months of stable shelf life and complete biological activity.
Q5: What does high-purity Baicalin look like?
A: High-purity Baicalin is uniform light yellow fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no discoloration and no deterioration.
Q6: Can I get free Baicalin samples?
A: Yes, we provide free Baicalin samples for academic research, pharmacological efficacy verification and product formula testing. Bulk orders support customized purity and professional light-proof vacuum packaging to meet scientific research and industrial production needs.
