Product Introduction
| Item | Specification |
| Product Name | Astragaloside IV |
| Synonyms | Astragaloside 4; AS-IV; Cycloastragenol-3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranoside |
| CAS Number | 84687-43-4 |
| Molecular Formula | C₄₁H₆₈O₁₄ |
| Molecular Weight | 784.97 g/mol |
| Appearance | White fine crystalline powder, odorless, stable crystal texture, no caking under sealed dry and dark conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Premium Functional Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Assay |
| Production Method | Natural Astragalus Root Extraction + Macroporous Resin Isolation + Preparative HPLC Purification + Low-Temperature Recrystallization |
| Melting Point | 295–300°C (lit.) |
| Boiling Point | 927.2°C at 760 mmHg (Predicted) |
| Density | 1.34 g/cm³ at 25°C |
| Flash Point | 513.4°C |
| Solubility | Slightly soluble in water, freely soluble in methanol, ethanol, DMSO and pyridine; insoluble in chloroform and ether; stable in neutral and weakly acidic environments, sensitive to high temperature, strong acid and excessive humidity |
| Core Feature | Signature triterpene saponin marker of Astragalus membranaceus, multi-target organ-protective, immunomodulatory and anti-aging pure monomer |
| Package | 1g/5g/10g amber sealed bottle, 100g/1kg vacuum drum; moisture-proof & light-proof packaging, customized specifications supported |
| Storage | Store in vacuum-sealed, low-temperature, dry and dark conditions; avoid high temperature, humid air and strong acid contact to prevent molecular degradation and activity loss |
| Shelf Life | 24 months under standard sealed low-temperature dark storage |
Product Description
Astragaloside IV (AS-IV, CAS 84687-43-4) is the primary bioactive triterpene saponin purified from the dried roots of Astragalus membranaceus, a renowned traditional medicinal plant. As the definitive quality marker and most pharmacologically potent monomer in astragalus root extracts, Astragaloside IV features a unique cycloastragenol glycoside structure that delivers stable chemical properties and comprehensive multi-target biological activities. We supply premium research-grade and high-purity functional-grade Astragaloside IV powder with strictly controlled impurities, consistent batch activity and ultra-high single-component purity, fully compliant with global laboratory and functional ingredient production standards. Widely recognized for immunomodulation, multi-organ protection, anti-inflammation, antioxidation and anti-senescence capabilities, this natural saponin has become a core tool compound for modern pharmacological research and high-end anti-aging, immune-boosting raw material development.
Distinguished from mixed astragalus extracts and astragalus polysaccharides, pure Astragaloside IV possesses clear molecular structure, definite pharmacological targets and stable bioavailability, making it the gold-standard monomer for astragalus-related mechanism research. It exerts versatile regulatory effects on multiple human physiological systems, including immune, cardiovascular, nervous and renal systems. In immunological regulation, Astragaloside IV promotes immune cell proliferation, accelerates cytokine secretion and balances immune responses, effectively enhancing systemic immune defense and alleviating immune dysfunction. For organ protection, it improves myocardial microcirculation, inhibits cardiomyocyte apoptosis and reduces oxidative myocardial damage, providing reliable cardioprotective effects. Meanwhile, it repairs neuronal and renal tissue damage induced by oxidative stress and neuroinflammation, realizing dual neuroprotective and renoprotective functions.
In molecular pathway regulation, Astragaloside IV efficiently inhibits the overactivation of NF-κB, MAPK, p-Akt and p-mTOR signaling cascades, significantly reducing the release of pro-inflammatory cytokines and relieving chronic low-grade inflammation, a key driver of aging and chronic metabolic disorders. It also scavenges intracellular reactive oxygen species, mitigates lipid peroxidation damage and regulates cellular senescence progression, delivering dual anti-oxidative and anti-aging efficacy. Our high-precision purification process completely removes miscellaneous astragalus saponins, plant polysaccharides, fiber residues, heavy metals and organic solvent traces, eliminating experimental interference and ensuring pure monomer activity for high-precision scientific research and product formulation.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our Astragaloside IV adopts standardized industrial production workflows including selective plant extraction, macroporous resin gradient separation, preparative HPLC fine purification and multi-stage low-temperature recrystallization. The whole production process is conducted in a dust-free, light-shielded and temperature-controlled closed system to prevent structural degradation of the triterpene saponin active skeleton and retain complete biological activity. The finished product presents uniform white crystalline powder with stable texture, no agglomeration and no discoloration, meeting international research-grade and functional ingredient quality requirements.
Every batch of Astragaloside IV undergoes strict multi-dimensional quality verification via HPLC purity testing, NMR structural identification, mass spectrometry molecular confirmation and cell-level activity evaluation. Ultra-low residual impurities and excellent batch-to-batch consistency guarantee reliable experimental repeatability and stable product efficacy. With favorable solubility in common organic solvents and superior biocompatibility in cell culture and in vivo animal models, our Astragaloside IV fully adapts to diverse scientific research scenarios and high-end functional product development. We support bulk stable supply, customized purity grades and professional low-temperature light-proof packaging, providing cost-effective high-purity raw materials for global research institutions, pharmaceutical laboratories and health product manufacturers.
Functions & Benefits
Core Immunomodulatory & Immune Balancing Activity
Astragaloside IV acts as a potent natural immune regulator. It activates the proliferation and differentiation of immune cells, promotes the secretion of key immune cytokines, enhances body resistance against external stimuli, and regulates abnormal immune responses. It effectively improves low immunity and immune imbalance, serving as the core tool compound for immune pharmacology research and immune-enhancing ingredient development.
Excellent Cardioprotective & Cardiovascular Protection
High-purity Astragaloside IV optimizes myocardial blood microcirculation, suppresses cardiomyocyte oxidative stress and apoptosis, and alleviates myocardial ischemia-reperfusion injury. It stabilizes cardiovascular function, reduces vascular inflammatory damage, and provides reliable protective effects for cardiovascular health research and related functional product development.
Dual Neuroprotective & Renoprotective Effects
This natural triterpene saponin scavenges neuronal reactive oxygen species, inhibits neuroinflammation and protects neuronal activity and synaptic plasticity. It also improves renal microcirculation, reduces renal tubular inflammatory injury and oxidative damage, achieving systematic multi-organ protective efficacy for nerve and kidney tissues.
Anti-Inflammatory, Antioxidant & Anti-Aging Properties
Astragaloside IV blocks the activation of NF-κB and MAPK inflammatory signaling pathways, downregulates pro-inflammatory factor expression and relieves chronic low-grade inflammation. Its strong free radical scavenging capacity reduces intracellular oxidative damage, regulates cellular senescence pathways, and delays tissue and organ aging progression, delivering comprehensive anti-aging biological value.
Ultra-High Single-Component Purity & Zero Impurity Interference
Adopting multi-stage fine purification and low-temperature recrystallization technology, our Astragaloside IV completely removes miscellaneous saponins, plant polysaccharides and organic residues. It ensures 98%–99% high single-component purity, zero invalid impurity interference, and stable and consistent batch pharmacological activity.
High Safety & Wide Biocompatibility
Derived from natural medicinal plants, Astragaloside IV features low toxicity and excellent cellular biocompatibility. It maintains stable multi-target biological activity in cell experiments and animal models, perfectly adapting to pharmacological mechanism research, drug screening and functional health product formulation.
Applications
Immunopharmacology & Immune Regulation Research
Widely used as a standard immune-modulating monomer for exploring immune cell activation, cytokine regulation and immune balance mechanisms, extensively applied in immunology laboratory research and immune-enhancing functional product development.
Cardiovascular Pharmacology & Myocardial Protection Study
Served as a core experimental compound for researching myocardial injury repair, ischemia-reperfusion protection and cardiovascular microcirculation regulation, supporting pharmacological intervention research for cardiovascular diseases.
Neuroprotection & Renal Protection Mechanism Research
Applied in neuronal oxidative damage repair, neuroinflammation inhibition and renal tissue protection experiments, providing key monomer tools for multi-organ protection research and chronic organ disease auxiliary intervention studies.
Anti-Inflammation, Antioxidation & Anti-Senescence Research
Used for exploring chronic inflammatory pathway regulation, intracellular oxidative stress clearance and cellular senescence regulation mechanisms, widely adopted in anti-aging pharmacology and chronic metabolic disease research.
Medicinal Saponin Structure-Activity Relationship Research
As a typical cycloastragenol-type triterpene saponin marker compound, it is used for comparative analysis of saponin structure and activity differences, supporting natural active ingredient structure-activity relationship research.
Laboratory Teaching & Pharmacological Demonstration
Supplied as standard high-purity Astragaloside IV reagent for traditional Chinese medicine monomer pharmacology teaching, multi-organ protection and immune regulation mechanism demonstration, ensuring accurate and stable experimental data for scientific research and teaching.
FAQ
Q1: What is Astragaloside IV used for?
A: Astragaloside IV is the core active marker saponin of astragalus root. It is mainly applied in immune regulation research, cardiovascular, neural and renal multi-organ protection experiments, chronic anti-inflammatory and anti-aging mechanism studies, and high-end functional health ingredient production.
Q2: What are the advantages of Astragaloside IV over astragalus extracts?
A: Unlike mixed astragalus extracts with complex components and unstable activity, pure Astragaloside IV has a single definite structure, clear pharmacological targets, stable bioactivity and accurate experimental repeatability, making it the preferred monomer for precise mechanism research and high-standard product formulation.
Q3: What are your product advantages?
A: Our Astragaloside IV adopts preparative HPLC fine purification technology, achieving 98%–99% ultra-high purity, zero miscellaneous saponin and plant impurity interference, stable multi-organ protective and immune regulatory activity, and consistent batch quality for high-precision scientific research.
Q4: How to store Astragaloside IV properly?
A: Astragaloside IV is sensitive to high temperature, humidity and strong acid. It must be stored in vacuum-sealed, low-temperature, dry and dark environments. Standard professional storage guarantees 24 months of stable shelf life and complete biological activity.
Q5: What is the appearance of high-purity Astragaloside IV?
A: High-purity Astragaloside IV is uniform white fine crystalline powder at room temperature, with no peculiar smell, stable crystal state, no caking and no discoloration.
Q6: Can I get free samples of Astragaloside IV?
A: Yes, we provide free Astragaloside IV samples for academic research, pharmacological efficacy verification and product formula testing. Bulk orders support customized purity grades and professional vacuum light-proof packaging to meet research and industrial production demands.
