Product Introduction
| Item | Specification |
| Product Name | Febrifugine |
| Synonyms | Febrifugine base; Dichroine; 3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4(3H)-one |
| CAS Number | 24159-07-7 |
| Molecular Formula | C₁₆H₁₉N₃O₃ |
| Molecular Weight | 301.34 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal form under sealed dark and dry conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Pharma API Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Antimalarial Activity Detection |
| Production Method | Natural Dichroa Febrifuga Root & Leaf Extraction & Multi-Stage Resin Purification & Low-Temperature Recrystallization |
| Melting Point | 139–140°C / 154–156°C (lit.) |
| Boiling Point | 543.4°C at 760 mmHg |
| Density | 1.32 g/cm³ at 25°C |
| Flash Point | 261.1°C |
| Solubility | Soluble in methanol, ethanol, DMSO and chloroform; slightly soluble in water; stable in neutral and weak acidic conditions; sensitive to strong alkali and high temperature |
| Core Feature | Typical quinazolinone alkaloid, ultra-high potency natural antimalarial monomer, dual anti-inflammatory and immunomodulatory activity |
| Package | 1g/5g/10g sealed amber bottle, 100g/1kg drum; vacuum moisture-proof & light-proof packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature, dark and dry conditions; avoid high temperature, strong light and alkaline environment to prevent molecular structure degradation and activity loss |
| Shelf Life | 24 months under standard low-temperature sealed and dark storage |
Product Description
Our Febrifugine is a high-purity natural quinazolinone alkaloid with potent and specific biological activity, available in premium research grade and pharmaceutical API grade. Febrifugine (CAS 24159-07-7), also known as Dichroine, is the core active pharmacological monomer isolated and purified from the traditional Chinese medicinal plant Dichroa febrifuga. Possessing a unique quinazolinone heterocyclic structure combined with a hydroxypiperidine side chain, it is renowned as one of the most efficacious natural antimalarial alkaloids discovered to date, with far stronger plasmodium inhibitory activity than many conventional botanical antiparasitic monomers. Beyond its dominant antimalarial property, high-purity Febrifugine exhibits excellent anti-inflammatory, immunomodulatory and antiproliferative effects, making it a multi-functional lead compound for infectious disease pharmacology, immune regulation mechanism research and new antiparasitic drug development. As a professional bulk Febrifugine supplier, we provide low-impurity, high-activity, batch-stable Febrifugine raw materials for global tropical medicine laboratories, natural product research institutions and pharmaceutical R&D enterprises.
Febrifugine occupies a crucial position in the research of natural antiparasitic drugs and traditional medicinal alkaloids. First isolated and identified in 1947 from Dichroa febrifuga roots and leaves, this compound has become a classic research model for malaria treatment and infectious disease therapy. Its core pharmacological mechanism focuses on inhibiting plasmodium growth and reproduction by interfering with parasite protein synthesis and metabolic pathways, effectively killing various plasmodium schizonts and blocking malaria transmission. Compared with quinine and other common cinchona alkaloids, Febrifugine delivers significantly higher antimalarial potency at lower dosages, showing unique advantages in drug-resistant malaria strain research. In addition to antiparasitic efficacy, Febrifugine can effectively suppress the release of pro-inflammatory cytokines, regulate abnormal immune responses, and relieve inflammatory damage caused by pathogen infection, supporting in-depth research on infection-induced inflammation and immune disorder mechanisms. Its distinctive quinazolinone heterocyclic skeleton also provides valuable structural modification sites for the synthesis of high-efficiency, low-toxicity antimalarial and anti-inflammatory derivatives. Different from low-purity crude extracts containing plant impurities, isomer mixtures and residual pigments, our high-purity Febrifugine adopts precise gradient purification technology to remove all interfering impurities, ensuring single-component purity and ultra-stable biological activity for high-precision pharmacological experiments and preclinical drug research.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Febrifugine adopts advanced low-temperature selective solvent extraction combined with macroporous resin gradient separation and multi-stage low-temperature recrystallization purification process. The entire production process strictly controls temperature, pH and light shielding conditions, effectively avoiding structural decomposition and activity attenuation caused by high-temperature oxidation and alkaline hydrolysis. The closed oxygen-free production system thoroughly eliminates plant fiber residues, miscellaneous alkaloids, pigment impurities and organic solvent traces, completely retaining the complete quinazolinone active skeleton and efficient biological activity of Febrifugine. The finished product presents uniform white to off-white crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard natural product research grade and pharmaceutical botanical API grade quality specifications.
Every batch of Febrifugine undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell-level pharmacological activity testing. It achieves ultra-low trace residue and zero invalid impurity interference, ensuring consistent batch efficacy and excellent experimental repeatability. The product features stable solubility in common organic solvents and good biochemical compatibility in cell culture and in vivo animal experiment environments, fully meeting the strict raw material requirements of antimalarial drug screening, infectious inflammation model verification, immune regulation research and alkaloid derivative synthesis.
We maintain sufficient low-temperature light-proof inventory and complete qualification documents for bulk Febrifugine supply. Whether you need standard quinazolinone alkaloid monomers for basic pharmacological research, high-potency positive control reagents for antimalarial efficacy evaluation, or high-purity parent intermediates for new drug structural optimization, our premium Febrifugine is a high-cost-performance and high-value natural fine chemical product choice for global buyers.
Functions & Benefits
Ultra-High Potency Natural Antimalarial Activity (Core Benefit)
Febrifugine is a landmark high-efficiency natural antimalarial alkaloid. It specifically inhibits plasmodium protein synthesis and metabolic circulation, eliminates malaria parasites, and resists drug-resistant plasmodium strains. With stronger efficacy than traditional quinine-based alkaloids, it is the gold-standard tool compound for tropical malaria pharmacology research.
Unique Quinazolinone Heterocyclic Skeleton
Featuring a rare quinazolinone ring combined with a chiral hydroxypiperidine side chain, Febrifugine has a distinctive molecular structure different from conventional cinchona alkaloids. Its unique active skeleton provides irreplaceable templates for structural modification and innovative development of new antimalarial drugs.
Dual Anti-Inflammatory & Immunomodulatory Effects
High-purity Febrifugine effectively inhibits inflammatory factor overexpression, relieves pathogen-induced inflammatory responses, and regulates body immune balance. It supports multi-dimensional research on infectious inflammation, immune dysfunction and related disease mechanisms.
High Single-Component Purity & Zero Impurity Interference
Our Febrifugine adopts full-process low-temperature purification and multi-stage impurity removal technology, completely eliminating plant heterozygous impurities, isomer residues and pigment interference in traditional crude extracts. It ensures pure monomer activity and accurate experimental data for high-precision pharmacological research.
Strict Batch Consistency & Stable Biological Activity
Extracted and recrystallized under constant low-temperature sterile and light-shielded conditions, Febrifugine eliminates batch-to-batch quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent pharmacological activity, suitable for long-term drug screening and preclinical research projects.
Excellent Solubility & Wide Experimental Adaptability
Febrifugine has good solubility in DMSO, methanol, ethanol and chloroform, easy to prepare into homogeneous experimental stock solutions. It maintains stable activity in conventional cell and animal experiment environments, perfectly adapting to antimalarial tests, inflammatory model experiments and alkaloid derivative synthesis research.
Applications
Malaria & Drug-Resistant Parasite Research
Used as a high-potency standard antimalarial positive reagent for studying plasmodium inhibition mechanisms, parasite protein synthesis pathways and drug-resistant malaria strain resistance mechanisms, widely applied in tropical medicine and pathogenic biology laboratories.
Infectious Inflammation & Immune Regulation Study
Served as the core experimental compound for exploring infection-induced inflammatory responses and immune regulatory mechanisms, supporting efficacy verification and mechanism research of new anti-inflammatory and immunomodulatory natural drugs.
Novel Antimalarial Drug R&D & Structural Optimization
Applied as a high-value lead compound and parent skeleton for innovative antimalarial drug development, guiding structural modification, potency optimization and toxicity reduction of quinazolinone alkaloid derivatives.
Natural Alkaloid Structure-Activity Relationship Research
Used as a typical quinazolinone alkaloid model compound for studying the structure-activity relationship of heterocyclic skeletons and chiral side chains, enriching the theoretical system of natural alkaloid pharmacology.
Laboratory Teaching & Pharmacological Mechanism Demonstration
Provided as standard high-purity Febrifugine reagent for natural medicinal chemistry teaching experiments, antimalarial pharmacology demonstration and alkaloid activity comparison tests, ensuring accurate and stable experimental data for scientific research and teaching work.
FAQ
Q1: What is Febrifugine mainly used for?
A: Febrifugine is a high-efficiency natural quinazolinone antimalarial alkaloid. It is mainly used for malaria and drug-resistant plasmodium mechanism research, antimalarial drug screening, infectious inflammation and immune regulation research, and novel alkaloid derivative synthesis.
Q2: What is the advantage of Febrifugine over other antimalarial alkaloids?
A: Febrifugine has significantly stronger antimalarial potency than conventional quinine alkaloids, with excellent inhibitory effect on drug-resistant malaria strains. It also owns dual anti-inflammatory and immunomodulatory activities, featuring broader research value and better structural modification potential.
Q3: What are the core advantages of our Febrifugine?
A: Our Febrifugine adopts professional low-temperature purification technology, featuring ultra-high single-component purity, zero miscellaneous impurity and isomer interference, stable high-potency antimalarial activity and consistent batch efficacy, ensuring high-precision and repeatable pharmacological research results.
Q4: How to store Febrifugine correctly?
A: Febrifugine is sensitive to high temperature, strong light and alkaline environments, prone to structural degradation and activity loss. It must be stored in vacuum-sealed, low-temperature, light-proof and dry dark conditions. Standard sealed low-temperature dark storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Febrifugine?
A: High-purity Febrifugine is uniform white to off-white fine crystalline powder at room temperature, odorless, stable crystal state, no caking, no fading and no deterioration.
Q6: Can I get free Febrifugine samples for testing?
A: Yes, we provide free Febrifugine samples for antimalarial mechanism research, inflammatory immunity verification and new drug derivative synthesis experiments. Bulk orders support customized purity and professional light-proof vacuum packaging to meet high-standard scientific research and pharmaceutical API production needs.
