Product Introduction
| Item | Specification |
| Product Name | Indole-3-carbinol (I3C) |
| Synonyms | 吲哚-3-甲醇; 3-吲哚甲醇; I3C; 3-Indolemethanol; 1H-Indole-3-methanol |
| CAS Number | 700-06-1 |
| Molecular Formula | C₉H₉NO |
| Molecular Weight | 147.18 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal form under low-temperature sealed and dark conditions |
| Purity (HPLC) | ≥98.0% / ≥99.0% (Research Grade / Biotech Grade / Nutritional Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / NMR / Mass Spectrometry / IR Spectrum / Biological Activity Detection |
| Production Method | Indole Derivative Synthesis & Multi-Stage Purification & Low-Temperature Recrystallization |
| Melting Point | 96–99°C (lit.) |
| Boiling Point | 360.6°C at 760 mmHg |
| Density | 1.272 g/cm³ at 25°C |
| Flash Point | 171.9°C |
| Solubility | Slightly soluble in cold water, soluble in ethanol, methanol, DMSO and polar organic solvents, unstable in acidic aqueous solution, stable in low-temperature neutral environment |
| Core Feature | Natural bioactive indole compound, downstream Tryptophan metabolite, specific AhR agonist, powerful antioxidant and cell signal regulation activity |
| Package | 10g/100g sealed amber bottle, 1kg/5kg drum; vacuum moisture-proof low-temperature packaging, custom specification available |
| Storage | Store in vacuum-sealed, low-temperature (-20°C recommended), dark and dry conditions; avoid acidic environment, high temperature and long-term light exposure to prevent molecular transformation and activity attenuation |
| Shelf Life | 24 months under standard low-temperature sealed storage |
Product Description
Our Indole-3-carbinol (I3C) is a high-purity natural bioactive indole monomer with stable molecular structure and complete biological activity, available in premium nutritional grade, biotech grade and high-precision research grade. Indole-3-carbinol (CAS 700-06-1) is a classic indole derivative closely linked to the Tryptophan metabolic system, naturally extracted and biotransformed from cruciferous vegetables such as broccoli and cabbage. Different from acidic Indole-3-acetic Acid (IAA) for plant growth regulation and amine-type indoles (Serotonin, Melatonin) for human neural regulation, I3C features unique hydroxymethyl indole structure, focusing on AhR signal activation, antioxidant protection, cell cycle regulation and nutritional intervention research. As a professional bulk Indole-3-carbinol supplier, we provide low-impurity, high-stability, batch-consistent I3C raw materials for global biomedical research institutions, nutritional health product enterprises and indole derivative synthesis laboratories.
Indole-3-carbinol holds irreplaceable research value in cell biology, signal transduction pharmacology and functional nutrition. As a high-specificity endogenous AhR (Aryl Hydrocarbon Receptor) agonist, I3C can effectively activate downstream signal pathways, regulate cell proliferation, differentiation and apoptosis, and participate in immune balance and metabolic homeostasis regulation. It is widely used in cancer chemoprevention mechanism research, cellular antioxidant stress experiments and hormone balance regulation studies. In nutritional research, I3C serves as a core functional ingredient for body oxidation resistance and physiological balance maintenance, with excellent biocompatibility and nutritional safety. In fine chemical synthesis, its active hydroxymethyl-modified indole skeleton provides efficient modification sites, supporting the synthesis of high-value indole derivatives such as DIM (3,3′-Diindolylmethane) and other targeted bioactive molecules. Compared with ordinary low-purity I3C products prone to acidic transformation and impurity generation, our high-purity purified product eliminates synthetic residues, transitional transformation impurities and unstable by-products, ensuring single-component purity and stable biological activity for accurate and repeatable experimental data and consistent nutritional application effects.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Indole-3-carbinol adopts advanced indole precision synthesis combined with low-temperature oxygen-free reaction and multi-stage gradient recrystallization purification process. The entire production process strictly controls reaction pH, temperature and purification gradient, completely removing unreacted indole raw materials, solvent residues and unstable intermediate impurities. By adopting low-temperature sterile purification technology, it effectively avoids molecular structural transformation and activity degradation caused by high temperature and acidic conditions, fully retaining the complete hydroxymethyl indole active skeleton and specific AhR activation activity of I3C. The finished product presents uniform white crystalline powder, stable crystal form, no caking, no discoloration and no deterioration, fully complying with high-standard biomedical research grade, biotech experimental grade and nutritional food grade quality requirements.
Every batch of Indole-3-carbinol undergoes strict multi-dimensional quality inspection, including HPLC high-precision purity analysis, NMR structural verification, mass spectrometry molecular identification and cell biological activity testing. It ensures zero invalid impurity interference, ultra-low trace residues and consistent batch activity, providing reliable raw material guarantee for AhR signal pathway research, antioxidant pharmacological experiments and indole derivative synthesis. The product features good solubility in polar organic solvents, stable biochemical activity in neutral low-temperature environments and excellent cell compatibility, fully meeting the strict raw material requirements of cell culture experiments, in vitro pharmacological testing and functional nutritional product development.
We maintain sufficient low-temperature inventory and complete qualification documents for bulk Indole-3-carbinol supply. Whether you need standard AhR agonist monomers for biomedical research, core functional raw materials for antioxidant health products, or high-purity indole intermediates for custom derivative synthesis, our premium I3C is a high-cost-performance and high-value biological fine chemical product choice for global buyers.
Functions & Benefits
Specific AhR Receptor Agonist Activity (Core Benefit)
Indole-3-carbinol is a classic high-efficiency endogenous AhR agonist, which can specifically activate aryl hydrocarbon receptor signal pathways, regulate cell cycle progression, inhibit abnormal cell proliferation, and mediate immune and metabolic balance. It is the core standard tool compound for AhR pharmacological and cell signal research.
Important Downstream Metabolite of Tryptophan
As a key functional derivative of the indole metabolic system, I3C complements the Tryptophan-Serotonin-Melatonin neural regulation axis and IAA plant regulation system. It enriches the multi-scenario application research of indole compounds in animals, plants and nutritional metabolism, forming a complete indole biochemistry research system.
Powerful Antioxidant & Cytoprotective Effect
High-purity I3C has excellent free radical scavenging capacity, which can effectively reduce cellular oxidative stress damage, inhibit inflammatory responses, protect normal cell activity, and support research on anti-oxidation, anti-aging and cell protection mechanisms.
Low-Transformation Purification & Ultra-Stable Activity
Our Indole-3-carbinol adopts low-temperature oxygen-free and neutral environment purification technology, which effectively inhibits the acidic transformation and molecular rearrangement of conventional I3C products. It maintains long-term stable single-component purity and biological activity, ensuring high experimental repeatability.
Strict Batch Consistency & High Biocompatibility
Synthesized and recrystallized under constant low-temperature sterile conditions, I3C eliminates process quality fluctuations. The product has uniform crystal form, stable molecular structure and consistent batch efficacy, suitable for long-term cell research projects and standardized nutritional product development.
Excellent Solubility & Formula Adaptability
I3C has good solubility in common polar organic solvents, easy to prepare into experimental stock solutions and nutritional formula systems. It maintains stable activity in neutral and low-temperature environments, perfectly adapting to cell experiments, pharmacological testing and health product processing scenarios.
Applications
Cell Signal & AhR Pathway Research
Used as a standard high-purity AhR agonist reagent for studying aryl hydrocarbon receptor signal transduction, cell cycle regulation, immune metabolism and abnormal cell growth mechanisms. Widely applied in cell biology laboratories and pharmacological research institutions.
Antioxidant & Cytoprotective Pharmacological Study
Served as the core active indole monomer for oxidative stress research, anti-inflammatory and cell protection experiments, supporting the mechanism exploration of anti-oxidation, anti-aging and tissue damage repair.
Functional Nutritional Product Development
Applied as a high-safety natural functional raw material for antioxidant nutritional supplements, hormone balance conditioning products and metabolic health formulations, meeting nutritional grade safety standards for daily health regulation.
Indole Derivative Custom Synthesis
Used as the core hydroxymethyl indole skeleton intermediate for the synthesis of high-value indole derivatives such as DIM, supporting structural optimization and efficacy upgrading of targeted bioactive molecules and new pharmacological compounds.
Laboratory Formula Debugging & Biochemical Research
Provided as standard high-purity Indole-3-carbinol reagent for indole metabolic pathway verification, cell pharmacological efficacy testing and custom biochemical derivation experiments, ensuring accurate data and stable experimental effects for scientific research.
FAQ
Q1: What is Indole-3-carbinol (I3C) mainly used for?
A: Indole-3-carbinol is a natural bioactive indole compound and specific AhR agonist. It is mainly used for cell signal pathway research, antioxidant and cytoprotective pharmacological experiments, functional nutritional product development and high-value indole derivative synthesis, with unique cell regulation and metabolic balancing activity.
Q2: What is the relationship between I3C and Tryptophan metabolic system?
A: I3C is an important functional derivative of the Tryptophan-based indole metabolic family. Together with Serotonin, Melatonin and IAA, it forms a complete indole compound research system covering neural regulation, plant growth and cell metabolism, which is an important branch of indole biochemistry cross-domain research.
Q3: What are the core advantages of our Indole-3-carbinol?
A: Our I3C adopts low-temperature oxygen-free anti-transformation purification technology, featuring ultra-high single-component purity, zero transformation impurity interference, stable AhR agonist activity and consistent batch efficacy. It solves the instability problem of conventional I3C products, ensuring accurate and reliable experimental and application results.
Q4: How to store Indole-3-carbinol correctly?
A: I3C is sensitive to high temperature, light and acidic environments, prone to molecular rearrangement and structural transformation leading to activity loss. It must be stored in vacuum-sealed, low-temperature (-20°C recommended), dark and dry neutral conditions. Standard low-temperature sealed storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity I3C?
A: High-purity Indole-3-carbinol is uniform white to off-white crystalline powder at room temperature, odorless, stable crystal state, no caking, no discoloration and no impurity precipitation.
Q6: Can I get free I3C samples for testing?
A: Yes, we provide free Indole-3-carbinol samples for cell signal research, antioxidant verification and indole derivative synthesis tests. Bulk orders support customized purity and professional low-temperature anti-transformation packaging to meet high-standard scientific research and industrial production needs.
