Product Introduction
| Item | Specification |
| Product Name | Milrinone |
| Synonyms | Win 47203; Primacor; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile |
| CAS Number | 78415-72-2 |
| Molecular Formula | C₁₂H₉N₃O |
| Molecular Weight | 211.22 g/mol |
| Appearance | White to off-white crystalline powder, odorless, stable crystal morphology at room temperature |
| Purity (HPLC/GC) | ≥98.0% / ≥99.0% (Pharma Grade / Research Grade, customizable) |
| Loss on Drying | ≤ 0.2% |
| Residue on Ignition | ≤ 0.1% |
| Testing Method | HPLC / GC / NMR / Mass Spectrometry / IR Spectrum |
| Production Method | Precision Heterocyclic Synthesis & Multi-Stage Recrystallization & High-Purity Purification |
| Melting Point | 302–304°C (lit.) |
| Boiling Point | 473.1°C at 760 mmHg |
| Density | 1.34 g/cm³ at 25°C |
| Flash Point | 239.9°C |
| Solubility | Slightly soluble in water, soluble in methanol, ethanol, DMSO and polar organic solvents, stable in neutral and weakly acidic reaction systems |
| Core Feature | Stable bipyridine heterocyclic skeleton, specific PDE3 inhibitory activity, potent inotropic and vasodilatory biological function |
| Package | 10g/100g sealed amber bottle, 1kg/5kg drum; custom packaging available |
| Storage | Store in sealed, cool, dark and dry conditions; avoid high temperature, strong light and humid environment to prevent structural oxidation and activity degradation |
| Shelf Life | 24 months under standard sealed storage |
Product Description
Our Milrinone is a high-purity pharmaceutical-grade bipyridine heterocyclic compound with stable targeted biological activity, available in 98% and 99% premium grades. Milrinone (CAS 78415-72-2) is a classic and highly specific PDE3 inhibitor in cardiovascular pharmacology and fine chemical industry. Different from conventional pyridine derivatives such as Pyridoxine used for nutritional metabolism and Sulfapyridine focused on antibacterial research, Milrinone is professionally positioned in cardiovascular pharmacological research, phosphodiesterase target verification and cardiac drug intermediate synthesis, featuring a unique stable bipyridine cyclic skeleton and efficient targeted enzyme inhibitory activity. As a professional bulk Milrinone supplier, we provide low-impurity, high-specificity, batch-stable PDE3 inhibitor monomers for global biomedical research institutions, cardiovascular pharmaceutical R&D enterprises and fine chemical customization factories.
Milrinone holds irreplaceable core value in cardiovascular biomedical research and drug development. As a typical selective phosphodiesterase 3 inhibitor, it can effectively inhibit PDE3 enzyme activity, increase intracellular cAMP concentration, thereby enhancing myocardial contractility and producing significant vasodilatory effects. It is widely used in experimental research on acute decompensated heart failure, pulmonary arterial hypertension and cardiac circulatory regulation. In fine chemical synthesis, its rigid bipyridine heterocyclic structure provides stable modification sites, supporting structural optimization and derivative development of new cardiovascular drugs. Compared with low-purity industrial-grade Milrinone with miscellaneous hetero-impurities and unstable targeting activity, our high-purity purified product eliminates unreacted intermediates, structural isomers and solvent residues, ensuring ultra-high single-component purity and highly repeatable pharmacological experimental data.
Manufactured by Shaanxi BAISFU Bio-Engineering Co., Ltd., our premium Milrinone adopts advanced precision heterocyclic condensation synthesis technology combined with multi-stage low-temperature recrystallization and gradient high-precision impurity removal process. The entire production process is carried out under strict inert gas protection and constant temperature control, effectively avoiding molecular oxidation, skeleton distortion and by-product generation during synthesis. We precisely control reaction pH, temperature gradient and purification parameters to completely remove trace heavy metal residues, invalid isomer impurities and organic contaminants, fully retaining the complete bipyridine active skeleton and specific PDE3 inhibitory activity of Milrinone. The finished product presents uniform white crystalline powder, no caking, no discoloration, stable physical and chemical properties, fully compliant with pharmaceutical intermediate grade and high-standard biomedical research grade quality requirements.
Every batch of Milrinone undergoes strict multi-dimensional quality inspection, including HPLC high-precision chiral purity analysis, NMR structural verification, mass spectrometry molecular identification and trace impurity residue detection. It ensures zero invalid impurity interference, stable batch consistency and reliable targeted activity, providing solid raw material guarantee for cardiovascular mechanism research and PDE3-targeted new drug development. The product features moderate solubility in polar organic solvents, excellent structural stability in mild reaction environments and high derivatization potential, fully meeting the strict raw material standards of pharmacological efficacy testing, drug formula optimization and custom heterocyclic synthesis.
We maintain sufficient inventory and complete qualification documents for bulk Milrinone supply. Whether you need standard specific inhibitor monomers for cardiovascular biomedical experiments, core intermediates for PDE3-targeted drug derivative synthesis, or high-purity raw materials for pharmaceutical laboratory formula debugging, our pharmaceutical-grade Milrinone is a high-cost-performance and high-value fine chemical product choice for global buyers.
Functions & Benefits
Highly Specific PDE3 Inhibitory Activity (Core Benefit)
Milrinone acts as a selective phosphodiesterase 3 inhibitor, efficiently blocking PDE3-mediated cAMP degradation, elevating intracellular cAMP levels. It exerts stable positive inotropic and vasodilatory effects, serving as the gold standard experimental tool compound for cardiovascular circulation and heart failure mechanism research.
Stable Bipyridine Heterocyclic Intermediate
With rigid and integrated bipyridine molecular skeleton and multiple active functional groups, Milrinone has excellent structural stability and derivatization performance. It supports structural modification, functional group substitution and molecular optimization of various cardiovascular drug derivatives, with controllable reaction process and high finished product yield.
Professional Cardiovascular Pharmacology Research Reagent
High-purity Milrinone features single-component purity and highly specific biological activity, effectively avoiding non-specific binding interference. It is widely used in cardiac pharmacology experiments, pulmonary hypertension mechanism research and drug efficacy evaluation, ensuring high accuracy and repeatability of experimental data.
Ultra-Low Impurity & Stable Targeting Activity
Pharmaceutical-grade purified Milrinone removes heavy metal residues, organic impurities and structural isomer interference. It maintains stable targeted enzyme inhibitory activity, no adverse impact on cell experiments and pharmacological tests, ensuring consistent experimental and synthesis results across batches.
Strict Batch Consistency & Industrial Adaptability
Synthetic and recrystallized Milrinone eliminates raw material quality fluctuations. The product has uniform crystal form, stable molecular activity and consistent pharmacological effects, suitable for long-term scientific research projects and continuous industrial derivative production.
Excellent Solubility & Formula Compatibility
Milrinone has good solubility in common polar organic solvents and stable activity in neutral and weakly acidic systems. It is easy to dissolve and prepare into experimental stock solutions, with high formula compatibility, perfectly adapting to various pharmacological experiments and drug synthesis scenarios.
Applications
Cardiovascular Biomedical & Pharmacological Research
Used as a standard high-purity PDE3 inhibitor monomer for studying myocardial contractility regulation, vascular dilation mechanism, acute heart failure and pulmonary arterial hypertension pathogenesis. Widely applied in university laboratories, cardiovascular research institutes and pharmacological testing centers.
PDE3-Targeted Drug Derivative Synthesis
Served as the core bipyridine skeleton intermediate for structural modification and functional derivatization of new cardiovascular drugs, supporting the R&D of high-efficiency inotropic agents, vasodilators and targeted therapeutic molecules.
Pharmaceutical Intermediate Manufacturing
Applied in the production and upgrading of cardiovascular pharmaceutical raw materials, used for formula optimization and intermediate preparation of cardiac therapeutic preparations, meeting strict pharmaceutical-grade raw material quality standards.
Cell & Molecular Pharmacology Experiments
Used for cellular cAMP pathway verification, enzyme activity inhibition experiments and cardiovascular cell function regulation research, providing accurate and stable raw material support for molecular mechanism exploration.
Laboratory Scientific Research & New Drug Development
Provided as standard high-purity Milrinone monomer for target activity verification, synthetic process debugging and custom experimental development, supporting cardiovascular drug innovation and fine chemical product iteration.
FAQ
Q1: What is Milrinone mainly used for?
A: Milrinone is a high-value specific PDE3 inhibitor and cardiovascular pharmaceutical intermediate. It is mainly used for cardiovascular pharmacological mechanism research, PDE3-targeted drug derivative synthesis, myocardial function regulation experiments and pharmaceutical intermediate manufacturing, with stable inotropic and vasodilatory biological activity.
Q2: What is the core pharmacological characteristic of Milrinone?
A: Milrinone has highly selective PDE3 inhibitory activity, which can increase intracellular cAMP concentration, enhance myocardial contractility and dilate blood vessels. It features dual pharmacological effects of positive inotropy and vasodilation, making it a classic tool compound for heart failure and pulmonary hypertension research.
Q3: What are the core advantages of our Milrinone?
A: Our Milrinone adopts pharmaceutical-grade heterocyclic synthesis and multi-stage recrystallization purification technology. It features ultra-high single-component purity, ultra-low miscellaneous impurities, stable bipyridine skeleton structure and consistent targeted activity. It can effectively improve the accuracy of pharmacological experiments and the yield of derivative synthesis, with outstanding scientific research and industrial application advantages.
Q4: How to store Milrinone correctly?
A: Milrinone is sensitive to high temperature, strong light and humid environment, prone to molecular oxidation and activity attenuation. It needs to be stored in sealed, cool, dry and dark conditions. Standard sealed storage ensures 24 months of stable shelf life and biological activity.
Q5: What is the appearance of high-purity Milrinone?
A: High-purity Milrinone is uniform white to off-white crystalline powder at room temperature, odorless, stable crystal state, no caking, no discoloration and no visible impurity precipitation.
Q6: Can I get free Milrinone samples for testing?
A: Yes, we provide free Milrinone samples for cardiovascular pharmacological experiment verification, synthetic process debugging and new drug derivative development tests. Bulk orders support customized purity and packaging to meet industrial production and scientific research needs.
