(0.27 g, 1 mmol) was added to dichloromethane (5 ml) and stirred to dissolve. A 1 mol/L solution of BBr3 in dichloromethane (10 ml) was added dropwise, and the reaction was stirred at room temperature for 2 h, and the reaction was followed by TLC [developing solvent: acetone-hexane (1:2)]. The reaction mixture was poured into EtOAc (EtOAc m. Recrystallization from 50% ethanol gave white crystals (1) (0.20 g, 90%), mp 256 to 257.

[Pharmacological action] (1) Anti-tumor effect
(2) treatment of cardiovascular disease
(3) Antioxidant and anti-free radical action
(4) Liver protection
(5) estrogen-like effects and affect bone metabolism
(6) Regulating immunity
(7) Anti-virus
(8) Anti-bacteria and fungi
(9) Anti-allergic reaction
(10) Radiation protection
(11) Prevention of acute infectious atypical pneumonia
[Use] Widely used in medicine, health care products, cosmetics and food additives

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